Scientific article
Open access

Zinc homeostasis in Pseudomonas

Published inBioMetals
Publication date2022-12-06
First online date2022-12-06


In the genus Pseudomonas , zinc homeostasis is mediated by a complete set of import and export systems, whose expression is precisely controlled by three transcriptional regulators: Zur, CzcR and CadR. In this review, we describe in detail our current knowledge of these systems, their regulation, and the biological significance of zinc homeostasis, taking Pseudomonas aeruginosa as our paradigm. Moreover, significant parts of this overview are dedicated to highlight interactions and cross-regulations between zinc and copper import/export systems, and to shed light, through a review of the literature and comparative genomics, on differences in gene complement and function across the whole Pseudomonas genus. The impact and importance of zinc homeostasis in Pseudomonas and beyond will be discussed throughout this review.

Graphical abstract

  • ABC-transporters
  • CDF
  • CadR
  • CzcCBA
  • CzcR
  • CzcS
  • Metal transporters
  • P-type ATPase
  • Pseudomonas
  • Pseudopaline
  • RND
  • Zinc homeostasis
  • ZnuABC
  • Zur
Citation (ISO format)
DUCRET, Verena, GONZALEZ, Diego, PERRON, Karl. Zinc homeostasis in Pseudomonas. In: BioMetals, 2022. doi: 10.1007/s10534-022-00475-5
Main files (1)
Article (Published version)
ISSN of the journal0966-0844

Technical informations

Creation12/13/2022 8:14:00 AM
First validation12/13/2022 8:14:00 AM
Update time03/16/2023 10:14:06 AM
Status update03/16/2023 10:14:05 AM
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