UNIGE document Doctoral Thesis
previous document  unige:16570  next document
add to browser collection
Title

Development of new highly efficient amino-organocatalysts and of related methodologies

Author
Director
Defense Thèse de doctorat : Univ. Genève, 2011 - Sc. 4325 - 2011/06/20
Abstract The field of aminocatalysis, defined as the aptitude of a primary or secondary amine to catalyze reactions using carbonyls such as ketones or aldehydes, has rapidly evolved in the last ten years. These researches have led to considerable efforts in new catalysts developments. Unfortunately, most of the newly designed organocatalysts remain specific, as for the over-studied Michael addition to nitroolefins. Thus, the development of new catalysts with a broad range of applicability would be of great interest. During this phD, we discovered a new family of catalysts called Aminal PYrrolidine (APY). Based on a maximized steric hindrance and modularity of the catalysts, they afford excellent enantioselectivities on a broad range of different reactions. Furthermore, those catalysts were further applied to new highly challenging reactions. They allowed us to discover unprecedented reactions by applying new Michael acceptors and donors. In addition, by combining different modes of catalytic activation (organometallic and enamine) in a single-pot, a new approach for the generation of complex molecules has been explored.
Identifiers
URN: urn:nbn:ch:unige-165701
Full text
Thesis (5.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Citation
(ISO format)
QUINTARD, Adrien. Development of new highly efficient amino-organocatalysts and of related methodologies. Université de Genève. Thèse, 2011. https://archive-ouverte.unige.ch/unige:16570

248 hits

6 downloads

Update

Deposited on : 2011-07-05

Export document
Format :
Citation style :