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Scientific article
Open access
English

Longitudinal study of speech and dual-task performance in Parkinson's disease patients treated with subthalamic nucleus deep brain stimulation

Published inParkinsonism & related disorders, vol. 97, p. 75-78
Publication date2022-04
First online date2022-03-15
Abstract

Introduction: Impairments in speech and executive functions are both observed in Parkinson's disease (PD) and might be influenced by subthalamic nucleus deep brain stimulation (STN-DBS). We investigated the effects of STN-DBS on speech and executive functions and their mutual interference in PD.

Methods: 14 PD patients eligible for bilateral STN-DBS (PD-DBS), and 16 PD patients with best medical treatment (PD-BMT) were included. Global cognition, executive functions (inhibition and verbal fluency), speech tasks with acoustic measures, and a dual-task (DT) combining a speech task with a Go or Go/NoGo task were performed at baseline and 12 months follow-up. A normative group of matched healthy participants was included at baseline for the evaluation of speech and DT performance.

Results: In both patient groups, global cognition mildly decreased after 12 months (p < .001). PD-DBS showed decreased inhibition (p = .016) whereas PD-BMT deteriorated in vowel articulation (p = .011). Using the DT paradigm, PD-DBS showed a slowing of speech rate after 12 months (p = .009) in contrast to PD-BMT (p = .203).

Conclusion: STN-DBS does not seem to impair speech and global cognition but might affect certain executive functions (notably inhibition). Speech-cognition interference is relatively preserved in PD patients, even though PD-DBS present larger DT cost on speech rate at 12 months post-DBS compared to PD-BMT. An evaluation with a longer follow-up using a larger sample is needed to confirm long-term effects.

eng
Keywords
  • Deep brain stimulation
  • Dual-task
  • Executive functions
  • Global cognition
  • Parkinson's disease
  • Speech
  • Deep Brain Stimulation / adverse effects
  • Humans
  • Longitudinal Studies
  • Parkinson Disease / complications
  • Parkinson Disease / therapy
  • Speech
  • Subthalamic Nucleus / physiology
  • Task Performance and Analysis
Funding
  • Parkinson Schweiz -
Citation (ISO format)
CATALANO, Sabina et al. Longitudinal study of speech and dual-task performance in Parkinson’s disease patients treated with subthalamic nucleus deep brain stimulation. In: Parkinsonism & related disorders, 2022, vol. 97, p. 75–78. doi: 10.1016/j.parkreldis.2022.03.003
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Identifiers
ISSN of the journal1353-8020
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36downloads

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