Scientific article
Open access

Systemic effects of IL-6 blockade in rheumatoid arthritis beyond the joints

Published inCytokine, vol. 149, 155742
Publication date2022-01
First online date2021-10-20

Interleukin (IL)-6 is produced locally in response to an inflammatory stimulus, and is able to induce systemic manifestations at distance from the site of inflammation. Its unique signaling mechanism, including classical and trans-signaling pathways, leads to a major expansion in the number of cell types responding to IL-6. This pleiotropic cytokine is a key factor in the pathogenesis of rheumatoid arthritis (RA) and is involved in many extra-articular manifestations that accompany the disease. Thus, IL-6 blockade is associated with various biological effects beyond the joints. In this review, the systemic effects of IL-6 in RA comorbidities and the consequences of its blockade will be discussed, including anemia of chronic disease, cardiovascular risks, bone and muscle functions, and neuro-psychological manifestations.

  • IL-6 blockade
  • Interleukin-6
  • Rheumatoid arthritis
  • Systemic effects
  • Animals
  • Arthritis, Rheumatoid / metabolism
  • Bone and Bones / metabolism
  • Cytokines / metabolism
  • Humans
  • Inflammation / metabolism
  • Interleukin-6 / metabolism
  • Joints / metabolism
  • Signal Transduction / physiology
Citation (ISO format)
JARLBORG, Matthias, GABAY, Cem. Systemic effects of IL-6 blockade in rheumatoid arthritis beyond the joints. In: Cytokine, 2022, vol. 149, p. 155742. doi: 10.1016/j.cyto.2021.155742
Main files (1)
Article (Published version)
ISSN of the journal1043-4666

Technical informations

Creation08/21/2022 9:28:00 AM
First validation08/21/2022 9:28:00 AM
Update time03/16/2023 8:57:46 AM
Status update03/16/2023 8:57:46 AM
Last indexation08/31/2023 10:06:05 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack