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Scientific article
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Open access
French

Hypothyroïdie infraclinique : faut-il encore traiter les personnes âgées ? Implications cliniques d’une nouvelle étude en médecine de famille

Other titleSubclinical hypothyroidism : should we still treat elderly patients? Clinical implications of a new trial in primary care
Published inRevue médicale suisse, vol. 14, no. 596, p. 470-474
Publication date2018-02-28
Abstract

Subclinical hypothyroidism, defined as an elevated level of thyrotropin hormone (TSH) and normal thyroxin, is more frequent in women and above 65 years old. This condition is associated with an increased cardiovascular risk, in particular with TSH > 10,0 mIU/L. Although overt hypothyroidism is rare (prevalence of 0,3 %), levothyroxine has become the most prescribed medication in the US, while its indications are still debated. The European-funded TRUST trial showed no improvement in Hypothyroid Symptoms and Tiredness scores among patients ≥ 65 years with subclinical hypothyroidism treated with levothyroxine, and no improvement in blood pressure, weight, muscle strength and cognition. The results of this study call for a revision of the current international recommendations on the treatment of subclinical hypothyroidism.

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Keywords
  • Aged
  • Clinical Trials as Topic
  • Female
  • Humans
  • Hypothyroidism / drug therapy
  • Prevalence
  • Primary Health Care
  • Thyrotropin / therapeutic use
  • Thyroxine / therapeutic use
Research group
Citation (ISO format)
COLLET, Tinh-Hai et al. Hypothyroïdie infraclinique : faut-il encore traiter les personnes âgées ? Implications cliniques d’une nouvelle étude en médecine de famille. In: Revue médicale suisse, 2018, vol. 14, n° 596, p. 470–474. doi: 10.53738/REVMED.2018.14.596.0470
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1660-9379
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