The electric intracerebral stimulation (or deep brain stimulation, DBS) has been described already in 1912. Nowadays DBS is evaluated as a possible treatment of non-operable pharmacologically intractable epilepsy. We summarize the results of the different DBS studies in various brain structures. In particular, stimulation of the mesial temporal lobe structures appears to be successful. In our Geneva-Lausanne centre, this treatment was carried out in selected patients, with good results. Further studies are needed in order to optimize the stimulus parameters and to better define the patient population.