Scientific article

Metaproteome and metabolome of oral microbial communities

Published inPeriodontology 2000, vol. 85, no. 1, p. 46-81
Publication date2021-02
First online date2020-11-23

The emergence of high-throughput technologies for the comprehensive measurement of biomolecules, also referred to as "omics" technologies, has helped us gather "big data" and characterize microbial communities. In this article, we focus on metaproteomic and metabolomic approaches that support hypothesis-driven investigations on various oral biologic samples. Proteomics reveals the working units of the oral milieu and metabolomics unveils the reactions taking place; and so these complementary techniques can unravel the functionality and underlying regulatory processes within various oral microbial communities. Current knowledge of the proteomic interplay and metabolic interactions of microorganisms within oral biofilm and salivary microbiome communities is presented and discussed, from both clinical and basic research perspectives. Communities indicative of, or from, health, caries, periodontal diseases, and endodontic lesions are represented. Challenges, future prospects, and examples of best practice are given.

  • Biofilms
  • Humans
  • Metabolome
  • Microbiota
  • Periodontal Diseases
  • Proteomics
Affiliation Not a UNIGE publication
Citation (ISO format)
BOSTANCI, Nagihan et al. Metaproteome and metabolome of oral microbial communities. In: Periodontology 2000, 2021, vol. 85, n° 1, p. 46–81. doi: 10.1111/prd.12351
Main files (1)
Article (Published version)
ISSN of the journal0906-6713

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