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Scientific article
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English

The Biological Substrate of the Motoric Cognitive Risk Syndrome: A Pilot Study Using Amyloid-/Tau-PET and MR Imaging

Published inJournal of Alzheimer's disease, vol. 87, no. 4, p. 1483-1490
Publication date2022-06-14
Abstract

A cross-sectional pilot study to explore the biological substrate of the Motoric Cognitive Risk (MCR) syndrome in a Memory Clinic cohort, using a multimodal imaging approach, was conducted. Twenty participants were recruited and classified as MCR+/−. Amyloid- and tau-PET uptakes, temporal atrophy, white matter hyperintensities, lateral ventricular volume (LVV), and diffusion tensor parameters were compared between groups. No significant differences were found in imaging features related to Alzheimer’s disease or gross vascular damage. MCR+ patients had increased LVV and altered diffusion parameters in the superior corona radiata. Ventricular enlargement and microstructural damage of the surrounding white matter tracts could contribute to MCR pathophysiology.

eng
Keywords
  • Alzheimer’s disease
  • Diffusion MRI
  • Gait disorder
  • Lateral ventricles
  • Vascular dementia
Citation (ISO format)
BOMMARITO, Giulia et al. The Biological Substrate of the Motoric Cognitive Risk Syndrome: A Pilot Study Using Amyloid-/Tau-PET and MR Imaging. In: Journal of Alzheimer’s disease, 2022, vol. 87, n° 4, p. 1483–1490. doi: 10.3233/JAD-215461
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ISSN of the journal1387-2877
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Creation06/07/2022 6:26:00 AM
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