Scientific article
Open access

CAR T-Based Therapies in Lymphoma: A Review of Current Practice and Perspectives

Published inBiomedicines, vol. 10, no. 8, 1960
Publication date2022-08-12
First online date2022-08-12

While more than half of non-Hodgkin lymphomas (NHL) can be cured with modern frontline chemoimmunotherapy regimens, outcomes of relapsed and/or refractory (r/r) disease in subsequent lines remain poor, particularly if considered ineligible for hematopoietic stem cell transplantation. Hence, r/r NHLs represent a population with a high unmet medical need. This therapeutic gap has been partially filled by adoptive immunotherapy. CD19-directed autologous chimeric antigen receptor (auto-CAR) T cells have been transformative in the treatment of patients with r/r B cell malignancies. Remarkable response rates and prolonged remissions have been achieved in this setting, leading to regulatory approval from the U.S. Food and Drug Administration (FDA) of four CAR T cell products between 2017 and 2021. This unprecedented success has created considerable enthusiasm worldwide, and autologous CAR T cells are now being moved into earlier lines of therapy in large B cell lymphoma. Herein, we summarize the current practice and the latest progress of CD19 auto-CAR T cell therapy and the management of specific toxicities and discuss the place of allogeneic CAR T development in this setting.

  • Cellular therapy
  • Chimeric antigen receptor
  • Lymphoma
Citation (ISO format)
SHEIKH, Semira, MIGLIORINI, Denis, LANG, Noémie. CAR T-Based Therapies in Lymphoma: A Review of Current Practice and Perspectives. In: Biomedicines, 2022, vol. 10, n° 8, p. 1960. doi: 10.3390/biomedicines10081960
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Article (Published version)
ISSN of the journal2227-9059

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