Scientific article
Open access

COVID-19 vaccine guidelines was numerous in quantity but many lack transparent reporting of methodological practices

Published inJournal of clinical epidemiology, vol. 144, p. 163-172
Publication date2022-04
First online date2021-12-14

Objective: To describe the current status of COVID-19 vaccine guidelines.

Study design and setting: We searched databases, Google and guideline platforms to retrieve COVID-19 vaccine guidelines published between January 1, 2020 and July 8, 2021. We worked in pairs to identify the eligible guidelines and extract data of whether the methodology, funding, and conflict of interests were assessed/reported, and so on. Results were presented descriptively.

Results: A total of 106 COVID-19 vaccine guidelines were included. In the first half of 2021, on average 15 guidelines were published every month. Fifty (47.2%) guidelines addressed the vaccination of people with specific medical conditions, and 18 (17.0%) guidelines focused on adverse effects after vaccination. Only 28 (26.4%) guidelines reported the methodology they used. Four (3.8%) of guidelines assessed both the quality of evidence and strength of recommendations; 42 (39.6%) and 65 (61.3%) guidelines reported their funding sources and conflict of interest, respectively. Most guidelines were published in English (n = 92, 86.8%).

Conclusion: A high number of guidelines on COVID-19 vaccines have been published in the recent months, but most of them lack clear and transparent reporting of methodology, funding, and conflicts of interest. Rigorous methodological and reporting quality evaluation of these guidelines is needed.

  • COVID-19
  • Conflict of interest
  • Guideline
  • Methodology
  • Transparency
  • Vaccine
  • COVID-19 / prevention & control
  • COVID-19 Vaccines / therapeutic use
  • Databases, Factual
  • Humans
  • National Key Research and Development Program of China - [2018YFC1705500]
  • National Office for Philosophy and Social Sciences - [19ZDA142]
Citation (ISO format)
WANG, Zijun et al. COVID-19 vaccine guidelines was numerous in quantity but many lack transparent reporting of methodological practices. In: Journal of clinical epidemiology, 2022, vol. 144, p. 163–172. doi: 10.1016/j.jclinepi.2021.12.015
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Article (Published version)
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ISSN of the journal0895-4356

Technical informations

Creation07/29/2022 8:53:00 AM
First validation07/29/2022 8:53:00 AM
Update time03/16/2023 8:39:37 AM
Status update03/16/2023 8:39:33 AM
Last indexation02/01/2024 9:03:19 AM
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