en
Master
French

Biomaterials for mucosal vaccination

ContributorsBouchez, Hadrien
Master program titleMaitrise universitaire en pharmacie
Defense date2011
Abstract

Chitosan is a biocompatible polysaccharide of natural origin and has been the subject of interest for its use as a polymeric drug carrier materials in mucosal vaccination. Derivates of this biopolymer are regarded as being usable due to their biocompatibility, biodegradability, and absence of toxicity. As derivatives, trimethylated chitosan (TMC) and 6-O-carboxymethyl-N,N,N-trimethylchitosan (CM-TMC) polymers demonstrated beneficial water-solubility at physiological pH value. They also feature adjuvant properties by acting as permeation enhancers, transiently opening intercellular tight junctions. Thereby these polymers enable paracellular transport of drugs, which can be useful for the formulation of mucosal vaccines. Calu-3 cell monolayers are a valuable model for predicting paracellular transport kinetics in airway epithelia. Accordingly, the polymers will be tested in Calu-3 cells to study the contribution of these derivates on drug delivery at the respiratory epithelium.

eng
Keywords
  • Mucosal delivery
  • N-Trimethyl chitosan (TMC)
  • Carboxymethyl chitosan (CM-TMC)
  • Polymer synthesis
  • Cell cultures
  • Calu-3
  • TEER
Citation (ISO format)
BOUCHEZ, Hadrien. Biomaterials for mucosal vaccination. 2011.
Main files (1)
Master thesis
accessLevelRestricted
Identifiers
  • PID : unige:16461
148views
0downloads

Technical informations

Creation06/17/2011 11:21:00 AM
First validation06/17/2011 11:21:00 AM
Update time03/14/2023 4:52:31 PM
Status update03/14/2023 4:52:31 PM
Last indexation01/29/2024 7:12:01 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack