Scientific article
Open access

Role of Non-Invasive Respiratory Supports in COVID-19 Acute Respiratory Failure Patients with Do Not Intubate Orders

Published inJournal of clinical medicine, vol. 10, no. 13, 2783
Publication date2021-06-24
First online date2021-06-24

The current gold-standard treatment for COVID-19-related hypoxemic respiratory failure is invasive mechanical ventilation. However, do not intubate orders (DNI), prevent the use of this treatment in some cases. The aim of this study was to evaluate if non-invasive ventilatory supports can provide a good therapeutic alternative to invasive ventilation in patients with severe COVID-19 infection and a DNI. Data were collected from four centres in three European countries. Patients with severe COVID-19 infection were included. We emulated a hypothetical target trial in which outcomes were compared in patients with a DNI order treated exclusively by non-invasive respiratory support with patients who could be intubated if necessary. We set up a propensity score and an inverse probability of treatment weighting to remove confounding by indication. Four-hundred patients were included: 270 were eligible for intubation and 130 had a DNI order. The adjusted risk ratio for death among patients eligible for intubation was 0.81 (95% CI 0.46 to 1.42). The median length of stay in acute care for survivors was similar between groups (18 (10-31) vs. (19 (13-23.5); p = 0.76). The use of non-invasive respiratory support is a good compromise for patients with severe COVID-19 and a do not intubate order.

  • COVID-19
  • CPAP
  • High flow nasal cannula
  • Mechanical ventilation
  • Oxygenation
Affiliation Not a UNIGE publication
Citation (ISO format)
MEDRINAL, Clément et al. Role of Non-Invasive Respiratory Supports in COVID-19 Acute Respiratory Failure Patients with Do Not Intubate Orders. In: Journal of clinical medicine, 2021, vol. 10, n° 13, p. 2783. doi: 10.3390/jcm10132783
Main files (1)
Article (Published version)
Secondary files (1)
ISSN of the journal2077-0383

Technical informations

Creation03/25/2022 2:18:00 PM
First validation03/25/2022 2:18:00 PM
Update time03/16/2023 7:44:44 AM
Status update03/16/2023 7:44:41 AM
Last indexation05/06/2024 11:41:25 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack