An epigenetic signature in CD19-CAR T cells predicts clinical outcome

Simonetta, Federico; Bertoni, Francesco

doi:10.1016/j.trecan.2021.12.005

Scientific article

English

An epigenetic signature in CD19-CAR T cells predicts clinical outcome

ContributorsSimonetta, Federico; Bertoni, Francesco

Published inTrends in cancer, vol. 8, no. 2, p. 81-82

Publication date2022-02

First online date2021-12-28

Abstract

The potential impact of epigenetic profiles on adoptive T cell immunotherapies is currently unknown. In a recent study in the Journal of the National Cancer Institute, Garcia-Prieto et al. show that specific DNA methylation profiles of CD19-CAR T cells are associated with improved clinical outcome of patients with B cell malignancies.

Keywords

CAR T cells
Biomarker
Leukemia
Lymphoma
Methylation
Resistance

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)

Citation (ISO format)

SIMONETTA, Federico, BERTONI, Francesco. An epigenetic signature in CD19-CAR T cells predicts clinical outcome. In: Trends in cancer, 2022, vol. 8, n° 2, p. 81–82. doi: 10.1016/j.trecan.2021.12.005

Article (Published version)

Identifiers

PID : unige:163868
DOI : 10.1016/j.trecan.2021.12.005
PMID : 34972674

Journal ISSN2405-8025

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Creation22/03/2022 12:45:00

First validation22/03/2022 12:45:00

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Status update16/03/2023 07:43:47

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An epigenetic signature in CD19-CAR T cells predicts clinical outcome

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