HMGB1 promotes CXCL12‐dependent egress of murine B cells from Peyer&#039;s patches in homeostasis

Spagnuolo, Lorenzo; Puddinu, Viola; Boss, Noémie; Spinetti, Thibaud; Oberson, Anne; Widmer, Jerome; Mottas, Inès; Hotz, Christian; Bianchi, Marco E.; Uguccioni, Mariagrazia; Bourquin, Carole

doi:10.1002/eji.202049120

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Title		HMGB1 promotes CXCL12‐dependent egress of murine B cells from Peyer's patches in homeostasis
Authors		Spagnuolo, Lorenzo Puddinu, Viola Boss, Noémie Spinetti, Thibaud Oberson, Anne Widmer, Jerome Mottas, Inès Hotz, Christian Bianchi, Marco E. Uguccioni, Mariagrazia Bourquin, Carole show all authors [1 - 11]
Published in		European Journal of Immunology. 2021, vol. 51, no. 8, p. 1980-1991
Abstract		High mobility group box-1 protein (HMGB1) is an alarmin that, once released, promotes inflammatory responses, alone and as a complex with the chemokine CXCL12. Here, we report that the HMGB1–CXCL12 complex plays an essential role also in homeostasis by controlling the migration of B lymphocytes. We show that extracellular HMGB1 is critical for the CXCL12-dependent egress of B cells from the Peyer's patches (PP). This promigratory function of the complex was restricted to the PPs, since HMGB1 was not required for B-cell migratory processes in other locations. Accordingly, we detected higher constitutive levels of the HMGB1–CXCL12 complex in PPs than in other lymphoid organs. HMGB1–CXCL12 in vivo inhibition was associated with a reduced basal IgA production in the gut. Collectively, our results demonstrate a role for the HMGB1–CXCL12 complex in orchestrating B-cell trafficking in homeostasis, and provide a novel target to control lymphocyte migration in mucosal immunity.
Keywords		B-cell migration — Gut immune regulation — HMGB1 — IgA — Peyer's patches
Identifiers		DOI: 10.1002/eji.202049120 PMID: 34060652 PMCID: PMC8453951
Full text		Article (Published version) (1 MB) - Free access Other version: https://onlinelibrary.wiley.com/doi/10.1002/eji.202049120
Structures		Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences Faculté des sciences / Section des sciences pharmaceutiques
Research group		Immunopharmacologie du cancer
Projects		Swiss National Science Foundation: 310030_156372 Swiss National Science Foundation: 31003A_138284 Swiss National Science Foundation: PDFMP3_137079
Citation (ISO format)		SPAGNUOLO, Lorenzo et al. HMGB1 promotes CXCL12‐dependent egress of murine B cells from Peyer's patches in homeostasis. In: European Journal of Immunology, 2021, vol. 51, n° 8, p. 1980-1991. doi: 10.1002/eji.202049120 https://archive-ouverte.unige.ch/unige:163830