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HMGB1 promotes CXCL12‐dependent egress of murine B cells from Peyer's patches in homeostasis

Boss, Noémie
Spinetti, Thibaud
Oberson, Anne
Widmer, Jerome
Hotz, Christian
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Published in European Journal of Immunology. 2021, vol. 51, no. 8, p. 1980-1991
Abstract High mobility group box-1 protein (HMGB1) is an alarmin that, once released, promotes inflammatory responses, alone and as a complex with the chemokine CXCL12. Here, we report that the HMGB1–CXCL12 complex plays an essential role also in homeostasis by controlling the migration of B lymphocytes. We show that extracellular HMGB1 is critical for the CXCL12-dependent egress of B cells from the Peyer's patches (PP). This promigratory function of the complex was restricted to the PPs, since HMGB1 was not required for B-cell migratory processes in other locations. Accordingly, we detected higher constitutive levels of the HMGB1–CXCL12 complex in PPs than in other lymphoid organs. HMGB1–CXCL12 in vivo inhibition was associated with a reduced basal IgA production in the gut. Collectively, our results demonstrate a role for the HMGB1–CXCL12 complex in orchestrating B-cell trafficking in homeostasis, and provide a novel target to control lymphocyte migration in mucosal immunity.
Keywords B-cell migrationGut immune regulationHMGB1IgAPeyer's patches
PMID: 34060652
PMCID: PMC8453951
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Research group Immunopharmacologie du cancer
Swiss National Science Foundation: 310030_156372
Swiss National Science Foundation: 31003A_138284
Swiss National Science Foundation: PDFMP3_137079
(ISO format)
SPAGNUOLO, Lorenzo et al. HMGB1 promotes CXCL12‐dependent egress of murine B cells from Peyer's patches in homeostasis. In: European Journal of Immunology, 2021, vol. 51, n° 8, p. 1980-1991. doi: 10.1002/eji.202049120 https://archive-ouverte.unige.ch/unige:163830

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Deposited on : 2022-10-03

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