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Doctoral thesis
English

SARA endosome and Microtubule asymmetries in Zebrafish

Imprimatur date2022-07-21
Defense date2022-07-21
Abstract

Notch signalling pathway is evolutionarily conserved, in phylogenetically distant species from Drosophila (Insecta) to Zebrafish (Teleostei). Previous studies in the Gonzalez-Gaitan laboratory unravelled the role of SARA endosomes in the regulation of the Notch signal pathway showing that the controlled segregation of these endosomes in asymmetric cell division controls signalling through this pathway. The mechanisms leading to asymmetric SARA endosome segregation were characterized in fly sensory organ precursor by Derivery et al. In Zebrafish spinal cord, Kressmann et al. found that SARA1 endosomes were asymmetrically inherited between daughter cells during neural precursor cell division. However, the mechanism leading to the asymmetric segregation of SARA1 endosomes in Zebrafish remains unknown. In this work, I investigate the Zebrafish homologues of the fly proteins characterized by Derivery et al. to uncover the mechanism responsible for SARA1 endosome segregation in neural precursor cell divisions in a vertebrate. The characterization of this mechanism allows to understand the neurogenesis and development of Zebrafish central nervous system with potential translation in mammals and human biology.

eng
Keywords
  • SARA
  • Endosome
  • Notch
  • Microtubule
  • CAMSAP
Citation (ISO format)
RICHARD, Clément-Alexis. SARA endosome and Microtubule asymmetries in Zebrafish. 2022. doi: 10.13097/archive-ouverte/unige:163418
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Creation09/20/2022 1:24:00 PM
First validation09/20/2022 1:24:00 PM
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