Inhibition of the DAPKs-L13a axis prevents a GAIT-like motif-mediated HuR insufficiency in melanoma cells

Noulet, Fanny; Merat, Rastine

doi:10.1016/j.bbrc.2022.07.086

Scientific article

English

Inhibition of the DAPKs-L13a axis prevents a GAIT-like motif-mediated HuR insufficiency in melanoma cells

ContributorsNoulet, Fanny; Merat, Rastine

Published inBiochemical and biophysical research communications, vol. 626, p. 21-29

Publication date2022-10-20

First online date2022-08-06

Abstract

This mechanistic study follows the previous studIies DOI: 10.1016/j.bbrc.2019.06.154 and 10.1016/j.neo.2021.06.009 in which we investigate a strategy to reduce the proportion of slow-proliferating HuR^Low highly plastic cells in order to overcome the adaptive response/resistance of solid malignancies to small-molecule targeted therapies. The work is performed again in the paradigmatic melanoma model of adaptive resistance.

Keywords

Adaptive resistance
BRAF inhibition
DAPK
ZIPK
GAIT complex post-transcriptional expression regulation
GAIT RNA element
ELALVL1
HuR
RNA-binding protein
Melanoma
Small-molecule targeted therapy
Slow-proliferating cells
Senescent-like cells

Affiliation entities

Research groups

Inflammation cutanée (919)

Citation (ISO format)

NOULET, Fanny, MERAT, Rastine. Inhibition of the DAPKs-L13a axis prevents a GAIT-like motif-mediated HuR insufficiency in melanoma cells. In: Biochemical and biophysical research communications, 2022, vol. 626, p. 21–29. doi: 10.1016/j.bbrc.2022.07.086