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Scientific article
English

Simple method of in vitro diffusion of nicotine across porcine palatine mucosa

Published inEuropean journal of pharmaceutics and biopharmaceutics, vol. 43, no. 3, p. 259-264
Publication date1997-06
Abstract

The pig's palatal mucosa is used as a simple model of in vitro vertical diffusion to study the permeation of different dosage forms of nicotine. Nicotine-loaded microspheres as well as solutions are tested and some parameters of diffusion determined (fluxes, lag-time, etc.). The nicotine fluxes of solutions and microspheres do not differ significantly, except in the case of nicotine base formulations. However, the lag-time of microspheres formulations seems to be half the lag-time of solutions. The swelling of microspheres provoking a dehydration of the mucosa, as well as the high concentration of nicotine in microspheres directly in contact with the mucosa, seem to explain this difference of lag-time.

eng
Keywords
  • In vitro permeation
  • Pig's palatal mucosa
  • Nicotine
  • Microspheres
  • Franz cell
Citation (ISO format)
CORNAZ GUDET, Anne-Laurence, GANEM-QUINTANAR, Adriana, BURI, Pierre. Simple method of in vitro diffusion of nicotine across porcine palatine mucosa. In: European journal of pharmaceutics and biopharmaceutics, 1997, vol. 43, n° 3, p. 259–264. doi: 10.1016/S0939-6411(97)00049-0
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Article (Published version)
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ISSN of the journal0939-6411
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