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Scientific article
English

International survey of human herpes virus 8 screening and management in solid organ transplantation

Published inTransplant infectious disease, vol. 23, no. 5, e13698
Publication date2021-10
First online date2021-08-21
Abstract

Background: HHV-8/Kaposi Sarcoma herpesvirus has been associated with a broad spectrum of diseases in solid organ transplant (SOT) recipients. Primary donor-derived infection can be associated with severe and rapidly fatal non-neoplastic disease, and diagnosis is made with high HHV-8 DNAemia.

Methods: We carried out an international survey to investigate the current approach to HHV-8 screening, and management in SOT since a protocol has not been established by international guidelines.

Results: A total of 51 transplant centers from 15 countries filled out the survey. HHV-8-associated diseases in SOT have been diagnosed during the previous 5 years in 67% of centers. Pretransplant serological screening is performed in 17 centers (33%), and posttransplant HHV-8 nucleic acid testing (NAT) monitoring is performed in 21 centers (41%). Performing HHV-8 NAT monitoring and serological screening were found associated with having diagnosed in the previous 5 years a non-malignant HHV-8-associated disease.

Conclusions: Serological pretransplant screening of donors and recipients and post-transplant HHV-8 NAT monitoring recommendations should be standardized. Even though serological assays are not optimal, they could contribute to increasing knowledge on epidemiology and management of HHV-8-associated diseases after SOT.

eng
Keywords
  • Human herpes virus 8
  • Screening
  • Solid organ transplant
  • Survey
  • Herpesviridae Infections / diagnosis
  • Herpesviridae Infections / epidemiology
  • Herpesvirus 8, Human
  • Humans
  • Organ Transplantation / adverse effects
  • Sarcoma, Kaposi / epidemiology
  • Transplant Recipients
Citation (ISO format)
MULARONI, Alessandra et al. International survey of human herpes virus 8 screening and management in solid organ transplantation. In: Transplant infectious disease, 2021, vol. 23, n° 5, p. e13698. doi: 10.1111/tid.13698
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ISSN of the journal1398-2273
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