The intranasal route is of particular interest for administration of drugs to patients who cannot swallow easily. In this perspective, nasal dosage forms of metoclopramide, an antiemetic drug, were developed and tested on human volunteers. Drug plasma concentrations were assessed using an HPLC method specially developed in our laboratory. The administration of a solution, as well as two powder systems, provided therapeutic plasma levels. While a simple solution led to adequate absorption, hydrophilic microspheres significantly increased metoclopramide bioavailability.