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Scientific article
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English

Nasal Absorption of Metoclopramide Administered to Man

Published inEuropean journal of pharmaceutics and biopharmaceutics, vol. 40, no. 4, p. 228-231
Publication date1994
Abstract

The intranasal route is of particular interest for administration of drugs to patients who cannot swallow easily. In this perspective, nasal dosage forms of metoclopramide, an antiemetic drug, were developed and tested on human volunteers. Drug plasma concentrations were assessed using an HPLC method specially developed in our laboratory. The administration of a solution, as well as two powder systems, provided therapeutic plasma levels. While a simple solution led to adequate absorption, hydrophilic microspheres significantly increased metoclopramide bioavailability.

eng
Keywords
  • Nasal absorption
  • Metoclopramide
  • Powder system
  • Microcrystalline cellulose
  • Starch microspheres
Citation (ISO format)
VIVIEN CASTIONI, Nathalie Nadine et al. Nasal Absorption of Metoclopramide Administered to Man. In: European journal of pharmaceutics and biopharmaceutics, 1994, vol. 40, n° 4, p. 228–231.
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Article (Published version)
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Identifiers
  • PID : unige:162124
ISSN of the journal0939-6411
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