en
Scientific article
Open access
English

Mucoadhesive Semi-Solid Formulations for Intraoral Use Containing Sucralfate

Published inEuropean journal of pharmaceutics and biopharmaceutics, vol. 43, no. 2, p. 133-137
Publication date1996
Abstract

Highly viscous gels containing sucralfate and a local anesthetic, e.g. lidocaine, were formulated for application to oral mucosa. An ex vivo bioadhesion test was performed to compare different formulations. The bioadhesiveness increases when the water content of the formulation decreases. In vitro hydration tests show that this phenomenon is related to the initial dehydration capacity of the formulation. In vitro hydration tests with two commercially available hydrophilic and hydrophobic preparations (Pansoral® and Solcoseryl®) gave the same results. Formulations without water (hydrophobic formulation) have better bioadhesive properties on wet mucosa than those containing water (hydrophilic formulations). Polycarbophil and chitosan loose most of their bioadhesive properties when used in hydrophilic formulations.

eng
Keywords
  • Sucralfate
  • Local anesthetic
  • Bioadhesive oral dosage form
  • Ex vivo bioadhesion
  • Water uptake
Citation (ISO format)
NGUYEN-XUAN, Tho et al. Mucoadhesive Semi-Solid Formulations for Intraoral Use Containing Sucralfate. In: European journal of pharmaceutics and biopharmaceutics, 1996, vol. 43, n° 2, p. 133–137.
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
  • PID : unige:162008
ISSN of the journal0939-6411
152views
95downloads

Technical informations

Creation07/11/2022 7:25:00 AM
First validation07/11/2022 7:25:00 AM
Update time03/16/2023 6:58:03 AM
Status update03/16/2023 6:58:02 AM
Last indexation01/17/2024 8:57:49 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack