UNIGE document Scientific Article
previous document  unige:161701  next document
add to browser collection
Title

Influence of body mass index on clinical outcomes in venous thromboembolism: Insights from GARFIELD-VTE

Authors
Weitz, Jeffrey I
Farjat, Alfredo E
Ageno, Walter
Turpie, Alexander G G
Haas, Sylvia
Goto, Shinya
Goldhaber, Samuel Z
Angchaisuksiri, Pantep
show hidden authors show all authors [1 - 17]
Collaboration
Published in Journal of thrombosis and haemostasis. 2021, vol. 19, no. 12, p. 3031-3043
Abstract

Background: There is limited information on the influence of body mass index (BMI) on clinical outcomes in patients with venous thromboembolism (VTE).

Objectives: Investigate the influence of BMI on baseline characteristics, treatment patterns, and 24-month outcomes in VTE patients.

Methods: GARFIELD-VTE is a prospective, non-interventional study of 10 869 patients with objectively confirmed VTE. Patients were grouped according to BMI: <18.5 (underweight; n = 214); 18.5-24.9 (normal; n = 2866); 25.0-29.9 (overweight; n = 3326); ≥30 (obese; n = 3073).

Results: Compared with patients with a normal BMI, obese patients were more frequently Caucasian (77.4% vs. 57.9%), treated in the outpatient setting (30.4% vs. 23.1%), and had previous VTE (17.5% vs. 11.7%). Active cancer was associated with lower BMI (underweight: 30.4%, normal: 13.5%, overweight: 9.4%, obese: 7.0%). At baseline, overweight and obese patients less often received parenteral therapy alone (16.7% and 14.4%) compared with those with an underweight or normal BMI (30.8% and 21.6%). Obese patients more commonly remained on anticoagulants for ≥2-years compared to those with a normal BMI (52.3% vs. 37.7%). After 24-months, the risk of all-cause mortality was lower in overweight and obese patients than in those with normal BMI (adjusted hazard ratio [95% CI]; 0.75 [0.63-0.89] and 0.59 [0.49-0.72], respectively). Underweight patients more often experienced major bleeding (2.45 [1.41-4.26]) and all-cause mortality (1.90 [1.43-2.53]) than patients with a normal BMI. Recurrent VTE was comparable among groups.

Conclusion: Underweight VTE patients have the highest risk of mortality and major bleeding. The risk of mortality in obese VTE patients is lower than that in VTE patients with a normal BMI.

Keywords AnticoagulationBody mass indexObesityPulmonary embolismVenous thromboembolismAnticoagulants / therapeutic useBody Mass IndexHemorrhageHumansProspective StudiesVenous Thromboembolism / diagnosis
Identifiers
PMID: 34487616
Full text
Article (Published version) (1.7 MB) - document accessible for UNIGE members only Limited access to UNIGE
Appendix (1.3 MB) - document accessible for UNIGE members only Limited access to UNIGE
Other version: https://onlinelibrary.wiley.com/doi/10.1111/jth.15520
Structures
Research group La maladie thromboembolique veineuse (808)
Project
KANTOR CHARITABLE FOUNDATION
Citation
(ISO format)
WEITZ, Jeffrey I et al. Influence of body mass index on clinical outcomes in venous thromboembolism: Insights from GARFIELD-VTE. In: Journal of thrombosis and haemostasis, 2021, vol. 19, n° 12, p. 3031-3043. doi: 10.1111/jth.15520 https://archive-ouverte.unige.ch/unige:161701

14 hits

0 download

Update

Deposited on : 2022-06-24

Export document
Format :
Citation style :