NADPH Oxidases Connecting Fatty Liver Disease, Insulin Resistance and Type 2 Diabetes: Current Knowledge and Therapeutic Outlook

Nascè, Alberto; Gariani, Karim; Jornayvaz, François; Szanto, Ildiko

doi:10.3390/antiox11061131

Scientific article

Review

English

NADPH Oxidases Connecting Fatty Liver Disease, Insulin Resistance and Type 2 Diabetes: Current Knowledge and Therapeutic Outlook

Contributors

Nascè, Alberto; Gariani, Karim; Jornayvaz, François

; Szanto, Ildiko

Published in

Antioxidants, vol. 11, no. 6, 1131

Publication date

2022-06-09

First online date

2022-06-09

Abstract

Nonalcoholic fatty liver disease (NAFLD), characterized by ectopic fat accumulation in hepatocytes, is closely linked to insulin resistance and is the most frequent complication of type 2 diabetes mellitus (T2DM). One of the features connecting NAFLD, insulin resistance and T2DM is cellular oxidative stress. Oxidative stress refers to a redox imbalance due to an inequity between the capacity of production and the elimination of reactive oxygen species (ROS). One of the major cellular ROS sources is NADPH oxidase enzymes (NOX-es). In physiological conditions, NOX-es produce ROS purposefully in a timely and spatially regulated manner and are crucial regulators of various cellular events linked to metabolism, receptor signal transmission, proliferation and apoptosis. In contrast, dysregulated NOX-derived ROS production is related to the onset of diverse pathologies. This review provides a synopsis of current knowledge concerning NOX enzymes as connective elements between NAFLD, insulin resistance and T2DM and weighs their potential relevance as pharmacological targets to alleviate fatty liver disease.

Keywords

Hepatosteatosis
Nonalcoholic fatty liver disease
NAFLD
Reactive oxygen species
ROS
NADPH oxidase
NOX
Insulin resistance
Diabetes
Oxidative stress

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

UNIGE research groups

Funding

Swiss National Science Foundation - IL-18/IL-18BP balance in the crosstalk between inflammation and metabolic homeostasis [310030_189003]

Citation (ISO format)

NASCÈ, Alberto et al. NADPH Oxidases Connecting Fatty Liver Disease, Insulin Resistance and Type 2 Diabetes: Current Knowledge and Therapeutic Outlook. In: Antioxidants, 2022, vol. 11, n° 6, p. 1131. doi: 10.3390/antiox11061131

Article (Published version)

CC BY-4.0

Identifiers

PID : unige:161663
DOI : 10.3390/antiox11061131

Additional URL for this publication

https://www.mdpi.com/2076-3921/11/6/1131

Journal ISSN

2076-3921

295views

1547downloads

Creation

24/06/2022 07:54:00

First validation

24/06/2022 07:54:00

Update

06/01/2025 08:24:10

Status update

06/01/2025 08:24:10

Last indexation

06/01/2025 08:27:11

NADPH Oxidases Connecting Fatty Liver Disease, Insulin Resistance and Type 2 Diabetes: Current Knowledge and Therapeutic Outlook

Contributors

Published in

Publication date

First online date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Funding

Citation (ISO format)

Main files (1)

Identifiers

Additional URL for this publication

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation