Sialic acids: key determinants for invasion by the Apicomplexa

Friedrich, Nikolas; Matthews, Stephen; Soldati-Favre, Dominique

doi:10.1016/j.ijpara.2010.04.007

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Title		Sialic acids: key determinants for invasion by the Apicomplexa
Authors		Friedrich, Nikolas Matthews, Stephen Soldati-Favre, Dominique
Published in		International Journal for Parasitology. 2010, vol. 40, no. 10, p. 1145-54
Abstract		Sialic acids are ubiquitously found on the surface of all vertebrate cells at the extremities of glycan chains and widely exploited by viruses and bacteria to enter host cells. Carbohydrate-bearing receptors are equally important for host cell invasion by the obligate intracellular protozoan parasites of the phylum Apicomplexa. Host cell entry is an active process relying crucially on proteins that engage with receptors on the host cell surface and promote adhesion and internalisation. Assembly into complexes, proteolytic processing and oligomerization are important requirements for the functionality of these adhesins. The combination of adhesive proteins with varying stringency in specificity confers some flexibility to the parasite in face of receptor heterogeneity and immune pressure. Sialic acids are now recognised to critically contribute to selective host cell recognition by various species of the phylum.
Keywords		Animals — Apicomplexa/physiology — Host-Parasite Interactions — Ligands — Polysaccharides/metabolism — Sialic Acids/metabolism — Vertebrates/parasitology
Identifiers		DOI: 10.1016/j.ijpara.2010.04.007 PMID: 20430033
Full text		Article (Accepted version) (758 Kb) - Free access
Structures		Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire
Research group		Biologie d'un parasite intracellulaire obligatoire (773)
Citation (ISO format)		FRIEDRICH, Nikolas, MATTHEWS, Stephen, SOLDATI-FAVRE, Dominique. Sialic acids: key determinants for invasion by the Apicomplexa. In: International Journal for Parasitology, 2010, vol. 40, n° 10, p. 1145-54. doi: 10.1016/j.ijpara.2010.04.007 https://archive-ouverte.unige.ch/unige:16160