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Agency Deficits in a Human Genetic Model of Schizophrenia: Insights From 22q11DS Patients

Salomon, Roy
Kannape, Oliver Alan
Debarba, Henrique Galvan
Faivre, Nathan
Published in Schizophrenia bulletin. 2022, vol. 48, no. 2, p. 495-504
Abstract Schizophrenia is a chronic and disabling mental illness characterized by a disordered sense of self. Current theories suggest that deficiencies in the sense of control over one's actions (Sense of Agency, SoA) may underlie some of the symptoms of schizophrenia. However, it is not clear if agency deficits are a precursor or a result of psychosis. Here, we investigated full body agency using virtual reality in a cohort of 22q11 deletion syndrome participants with a genetic propensity for schizophrenia. In two experiments employing virtual reality, full body motion tracking, and online feedback, we investigated SoA in two separate domains. Our results show that participants with 22q11DS had a considerable deficit in monitoring their actions, compared to age-matched controls in both the temporal and spatial domain. This was coupled with a bias toward erroneous attribution of actions to the self. These results indicate that nonpsychotic 22q11DS participants have a domain general deficit in the conscious sensorimotor mechanisms underlying the bodily self. Our data reveal an abnormality in the SoA in a cohort with a genetic predisposition for schizophrenia, but without psychosis, providing evidence that deficits in delineation of the self may be a precursor rather than a result of the psychotic state.
Keywords LocomotionPsychosisSense of agencySensorimotor predictionVelocardiofacial syndromeVirtual reality22q11 Deletion Syndrome / complications22q11 Deletion Syndrome / geneticsAdolescentAdultChildFemaleHumansMaleModels, GeneticSchizophrenia / complicationsSchizophrenia / genetics
PMID: 34935960
PMCID: PMC8886583
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Research groups Laboratoire d'imagerie et de psychopathologie développementale (693)
Bertarelli Foundation
European Commission: MetAction
Swiss National Science Foundation: 324730_144260
Swiss National Science Foundation: 320030_179404
Swiss National Science Foundation: 200020_159968
Swiss National Science Foundation: 51NF40-185897
(ISO format)
SALOMON, Roy et al. Agency Deficits in a Human Genetic Model of Schizophrenia: Insights From 22q11DS Patients. In: Schizophrenia bulletin, 2022, vol. 48, n° 2, p. 495-504. doi: 10.1093/schbul/sbab143 https://archive-ouverte.unige.ch/unige:161526

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Deposited on : 2022-06-17

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