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A study of SOC, SAC and PLA2 inhibitors on muscle contraction characteristics

ContributorsDufour, Victor
Master program titleMaîtrise Universitaire en Pharmacie
Defense date2011
Abstract

A number of studies have reported chronic elevation in intracellular Ca2+ concentration in skeletal muscle fibers or in cultured myotubes from mdx mice (a mouse model for DMD)1. Two of the pathways that might be involved in the Ca2+ overload are store operated calcium channels (SOC) and stretch activated calcium channels (SAC). Earlier results suggest that both channels are controlled, at least partly, by the Ca2+ -independent form of phospholipase A2 (iPLA2)2. In the proposed work, the effect of inhibitors of PLA2, SAC and SOC will be studied using EDL-MDX-2 cell cultures. Selected compounds will be studied in isolated muscle contraction assays to determine their effects on force production, fatigue characteristics and muscular damage

eng
Keywords
  • DMD
  • Mdx
  • SOC
  • SAC
  • PLA2
Citation (ISO format)
DUFOUR, Victor. A study of SOC, SAC and PLA2 inhibitors on muscle contraction characteristics. 2011.
Main files (1)
Master thesis
accessLevelRestricted
Identifiers
  • PID : unige:16150
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Technical informations

Creation06/10/2011 11:18:00 AM
First validation06/10/2011 11:18:00 AM
Update time03/14/2023 4:52:13 PM
Status update03/14/2023 4:52:13 PM
Last indexation01/29/2024 7:10:57 PM
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