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Title

Ambulatory Blood Pressure in Relation to Plasma and Urinary Manganese

Authors
Zhang, Zhen-Yu
Carmeli, Cristian
Pruijm, Menno
Ackermann, Daniel
Petrović, Dušan
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Published in Hypertension. 2020, vol. 75, no. 4, p. 1133-1139
Abstract The association of blood pressure (BP) with manganese-an essential trace element required for human health-remains poorly studied. In 734 randomly recruited Swiss participants (mean age, 47.5 years; 51.4% women), we related ambulatory BP to 2 biomarkers, plasma manganese (pMn) and the urinary manganese (uMn) excretion. To allow for diurnal variation, we assessed BP and uMn over 24 hours and during wakefulness and sleep, using split urine samples. Twenty-four-hour, daytime, and nighttime systolic/diastolic BPs averaged 119.8/78.1, 123.8/81.2, and 107.0/68.3 mm Hg; the corresponding median uMn were 199.5, 83.0, and 51.5 μmol and median pMn, 0.52 μg/L. In analyses dichotomized by the median of the biomarkers, greater pMn was associated with higher 24-hour systolic/diastolic BP (+4.1/+2.3 mm Hg;P ≤ 0.0003), greater daytime uMn with lower daytime BP (-3.5/-1.9 mm Hg;P ≤ 0.0067), and greater nighttime uMn with higher nighttime BP (+2.9/+1.2 mm Hg;P ≤ 0.046). In multivariable-adjusted analyses, significance (P≤0.030) was retained for the positive association of 24-hour and daytime diastolic BP with pMn and for systolic BP in relation to uMn at night. The association sizes for a 2-fold increment in the biomarkers amounting to 0.77 mm Hg (95% CI, 0.08-1.47 mm Hg), 0.97 (CI, 0.20-1.76) and 1.33 (CI, 0.20-2.50 mm Hg), respectively. In conclusion, there were positive associations between diastolic BP and pMn over 24 hours and during daytime and between systolic BP and uMn at night.
Keywords Blood pressureEnvironmental exposureHumansHypertensionManganeseAdultAgedBiomarkers / metabolismBlood Pressure / physiologyBlood Pressure Monitoring, AmbulatoryCircadian Rhythm / physiologyFemaleHumansMaleManganese / bloodManganese / metabolismManganese / urineMiddle Aged
Identifiers
PMID: 32114854
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Structures
Research groups Groupe Pierre-Yves Martin (néphrologie) (30)
Médecine de 1er recours (1020)
Traits génétiques complexes (901)
Projects
Swiss National Science Foundation: 33CM30-124087
Swiss National Science Foundation: 51NF40-160620
Citation
(ISO format)
ZHANG, Zhen-Yu et al. Ambulatory Blood Pressure in Relation to Plasma and Urinary Manganese. In: Hypertension, 2020, vol. 75, n° 4, p. 1133-1139. doi: 10.1161/HYPERTENSIONAHA.119.13649 https://archive-ouverte.unige.ch/unige:161410

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Deposited on : 2022-06-14

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