Scientific article

Oméga-3 fortement dosés pour la prévention cardiovasculaire : une fausse bonne idée ?

Other title[High-dose Omega-3 for cardiovascular prevention, a bad idea?]
Published inRevue médicale suisse, vol. 18, no. 772, p. 434-437
Publication date2022-03-09

Hypertriglyceridemia is a cardiovascular risk factor independent of LDL cholesterol. Omega-3 reduce triglycerides levels, but without proven benefit to reduce cardiovascular risk. Recently, two studies on high-dose omega-3 derivatives have shown contradictory results on the risk of cardiovascular events: REDUCE-IT (4 g/day of icosapent ethyl) showed a 25 % reduction; STRENGTH (4 g/day of a mixture of eicosapentaenoic acid and docosahexaenoic acid) showed no effect. An increased risk of atrial fibrillation was observed in both studies. The European 2021 cardiovascular prevention guidelines propose to consider high-dose ethyl icosapent on a case-by-case basis in patients with hypertriglyceridemia.

  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / prevention & control
  • Fatty Acids, Omega-3 / therapeutic use
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Hypertriglyceridemia / complications
  • Hypertriglyceridemia / drug therapy
  • Triglycerides / therapeutic use
Citation (ISO format)
BERGER, Christine, GENCER, Baris, NANCHEN, David. Oméga-3 fortement dosés pour la prévention cardiovasculaire : une fausse bonne idée ? In: Revue médicale suisse, 2022, vol. 18, n° 772, p. 434–437. doi: 10.53738/REVMED.2022.18.772.434
Main files (1)
Article (Published version)
ISSN of the journal1660-9379

Technical informations

Creation04/01/2022 12:04:00 PM
First validation04/01/2022 12:04:00 PM
Update time03/16/2023 6:40:46 AM
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