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Scientific article
English

Low-Dose Radiation Therapy Reduces Amyloid Load in Young 3xTg-AD Mice

Published inJournal of Alzheimer's disease, vol. 86, no. 2, p. 641-653
Publication date2022-03-22
Abstract

Background: Low-dose radiation therapy (LD-RT) has been shown to decrease amyloidosis or inflammation in systemic diseases and has recently been proposed as possible treatment of Alzheimer's disease (AD). A positive effect of LD-RT on tauopathy, the other marker of AD, has also been suggested. These effects have been shown in preclinical studies, but their mechanisms are still not well understood.

Objective: This study aimed to evaluate if anti-amyloid and anti-inflammatory effects of LD-RT can be observed at an early stage of the disease. Its impact on tauopathy and behavioral alterations was also investigated.

Methods: The whole brain of 12-month-old 3xTg-AD mice was irradiated with 10 Gy in 5 daily fractions of 2 Gy. Mice underwent behavioral tests before and 8 weeks post treatment. Amyloid load, tauopathy, and neuroinflammation were measured using histology and/or ELISA.

Results: Compared with wild-type animals, 3xTg-AD mice showed a moderate amyloid and tau pathology restricted to the hippocampus, a glial reactivity restricted to the proximity of amyloid plaques. LD-RT significantly reduced Aβ42 aggregated forms (-71%) in the hippocampus and tended to reduce other forms in the hippocampus and frontal cortex but did not affect tauopathy or cognitive performance. A trend for neuroinflammation markers reduction was also observed.

Conclusion: When applied at an early stage, LD-RT reduced amyloid load and possibly neuroinflammation markers, with no impact on tauopathy. The long-term persistence of these beneficial effects of LD-RT should be evaluated in future studies.

eng
Keywords
  • Alzheimer’s disease
  • Amyloid
  • Neuroinflammation
  • Radiation therapy
  • Tau
Citation (ISO format)
CEYZERIAT, Kelly et al. Low-Dose Radiation Therapy Reduces Amyloid Load in Young 3xTg-AD Mice. In: Journal of Alzheimer’s disease, 2022, vol. 86, n° 2, p. 641–653. doi: 10.3233/JAD-215510
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ISSN of the journal1387-2877
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