en
Scientific article
Open access
English

High and low frequency electrical stimulation in non-lesional temporal lobe epilepsy

Published inSeizure, vol. 16, no. 8, p. 664-669
Publication date2007-12
First online date2007-06-19
Abstract

In patients with pharmacologically intractable epilepsy who are not eligible for surgery, deep brain stimulation is currently under evaluation as an alternative treatment. Optimal stimulation parameters, including high (HFS) versus low frequency (LFS) stimulation, are not well defined. Here, we report the effects of HFS (130 pulses per second, pps) and LFS (5pps) of the principal epileptogenic focus, in three patients with non-lesional temporal lobe epilepsy. HFS, but not LFS, was associated with a reduction of the interictal discharges and absence of seizures. HFS may be beneficial in patients with non-lesional temporal lobe epilepsy who are not surgical candidates.

eng
Keywords
  • Adult
  • Dose-Response Relationship, Radiation
  • Electric Stimulation / methods
  • Epilepsy, Temporal Lobe / therapy
  • Female
  • Humans
  • Male
Funding
  • FNS - [3200BO-104146]
  • Swiss National Science Foundation - Binaural cochlear implants for profoundly deaf patients: from psychophysics to speech reception
  • FNS - [320000-113766]
  • FNS - [114416]
Citation (ISO format)
BOEX, Colette et al. High and low frequency electrical stimulation in non-lesional temporal lobe epilepsy. In: Seizure, 2007, vol. 16, n° 8, p. 664–669. doi: 10.1016/j.seizure.2007.05.009
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1059-1311
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33downloads

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