Scientific article
Open access

Tumeur à cellules géantes de l’os

Other titleGiant cell tumor of bone
Published inRevue médicale suisse, vol. 17, no. 763, p. 2187-2191
Publication date2021-12-15

Giant cell tumor is a benign epiphyseo-metaphyseal bone tumor affecting the young patient. It is characterized by an extensive osteolysis, a high potential for recurrence, a risk of malignant transformation and pulmonary metastases. Curettage and cavity filling is the most common treatment, even in the case of a pathological fracture. A wide resection with prosthetic reconstruction must sometimes be considered. Better knowledge of the role of RANK-L in the pathophysiology of these tumors has led to clinical trials involving denosumab. Treatment with denosumab is suggested for inoperable lesions, or for aggressive lesions, in particular of the spine, pelvis, and sacrum before en bloc resection.

  • Bone Density Conservation Agents
  • Bone Neoplasms / therapy
  • Denosumab / therapeutic use
  • Fractures, Spontaneous
  • Giant Cell Tumor of Bone / therapy
  • Humans
  • Neoplasm Recurrence, Local
  • Treatment Outcome
Citation (ISO format)
BILLY, Jessica Marie et al. Tumeur à cellules géantes de l’os. In: Revue médicale suisse, 2021, vol. 17, n° 763, p. 2187–2191. doi: 10.53738/REVMED.2021.17.763.2187
Main files (1)
Article (Published version)
ISSN of the journal1660-9379

Technical informations

Creation12/22/2021 2:46:00 PM
First validation12/22/2021 2:46:00 PM
Update time03/16/2023 6:28:54 AM
Status update03/16/2023 6:28:53 AM
Last indexation01/17/2024 8:22:42 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack