en
Scientific article
Open access
English

Management and Outcome of Young Women (≤40 Years) with Breast Cancer in Switzerland

Published inCancers, vol. 14, no. 5, 1328
Publication date2022-03-04
First online date2022-03-04
Abstract

Background: An increase in breast cancer (BC) incidence in young women (YW) as well as disparities in BC outcomes have been reported in Switzerland. We sought to evaluate treatment and outcome differences among YW with BC (YWBC).

Methods: YW diagnosed with stage I-III BC between 2000-2014 were identified through nine cancer registries. Concordance with international guidelines was assessed for 12 items covering clinical/surgical management, combined in a quality-of-care score. We compared score and survival outcome between the two linguistic-geographic regions of Switzerland (Swiss-Latin and Swiss-German) and evaluated the impact of quality-of-care on survival.

Results: A total of 2477 women were included. The median age was 37.3 years (IQR 34.0-39.4 years), with 50.3% having stage II BC and 70.3% having estrogen receptor positive tumors. The mean quality-of-care score was higher in the Latin region compared to the German region (86.0% vs. 83.2%, p < 0.0005). Similarly, 5- and 10-year overall survival rates were higher in the Latin compared to the German region (92.3% vs. 90.2%, p = 0.0593, and 84.3% vs. 81.5%, p = 0.0025, respectively). There was no difference in survival according to the score. In the univariate analysis, women in the Latin region had a 28% lower mortality risk compared to women in the German region (hazard ratio 0.72; 95% CI 0.59-0.89). In the multivariable analysis, only stage, differentiation, tumor subtype and treatment period remained independently associated with survival.

Conclusions: We identified geographic disparities in the treatment and outcome of YWBC in Switzerland. National guidelines for YWBC should be implemented to standardize treatment. Awareness should be raised among YW and clinicians that BC does not discriminate by age.

eng
Keywords
  • Switzerland
  • Breast cancer
  • Management
  • Outcome
  • Young women
Funding
  • Swiss Cancer League - [HSR-4078-11-2016]
Citation (ISO format)
MONTAGNA, Giacomo et al. Management and Outcome of Young Women (≤40 Years) with Breast Cancer in Switzerland. In: Cancers, 2022, vol. 14, n° 5, p. 1328. doi: 10.3390/cancers14051328
Main files (1)
Article (Published version)
Secondary files (1)
Identifiers
ISSN of the journal2072-6694
154views
97downloads

Technical informations

Creation03/31/2022 10:39:00 AM
First validation03/31/2022 10:39:00 AM
Update time03/16/2023 6:27:38 AM
Status update03/16/2023 6:27:36 AM
Last indexation02/01/2024 8:09:28 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack