GSTM1 and GSTT1 double null genotypes determining cell fate and proliferation as potential risk factors of relapse in children with hematological malignancies after hematopoietic stem cell transplantation

Mlakar, Simona; Uppugunduri Satyanarayana, Chakradhara Rao; Nava, Tiago; Mlakar, Vid; Golay, Hadrien; Robin, Shannon Kristell Denise; Waespe, Nicolas; Rezgui, Mohamed-Ali; Chalandon, Yves; Boelens, Jaap Jan; Bredius, Robert G M; Dalle, Jean-Hugues; Peters, Christina; Corbacioglu, Selim; Bittencourt, Henrique; Krajinovic, Maja; Ansari Djaberi, Marc Georges; paediatric diseases working party of the European society for blood and marrow transplantation

doi:10.1007/s00432-021-03769-2

Scientific article

English

GSTM1 and GSTT1 double null genotypes determining cell fate and proliferation as potential risk factors of relapse in children with hematological malignancies after hematopoietic stem cell transplantation

ContributorsMlakar, Simona; Uppugunduri Satyanarayana, Chakradhara Rao

; Nava, Tiago; Mlakar, Vid; Golay, Hadrien; Robin, Shannon Kristell Denise; Waespe, Nicolas; Rezgui, Mohamed-Ali; Chalandon, Yves; Boelens, Jaap Jan; Bredius, Robert G M; Dalle, Jean-Hugues; Peters, Christina; Corbacioglu, Selim; Bittencourt, Henrique; Krajinovic, Maja; Ansari Djaberi, Marc Georges

; paediatric diseases working party of the European society for blood and marrow transplantation

Published inJournal of cancer research and clinical oncology, vol. 148, no. 1, p. 71-86

Publication date2022-01

First online date2021-09-09

Abstract

This study aimed to retrospectively evaluate the genetic association of null variants of glutathione S-transferases GSTM1 and GSTT1 with relapse incidence in children with hematological malignancies (HMs) undergoing busulfan (BU)- containing allogeneic hematopoietic stem cell transplantation (HSCT) and to assess the impact of these variants on BU-induced cytotoxicity on the immortalized lymphoblastoid cell lines (LCLs) and tumor THP1 GST gene-edited cell models.

Keywords

Acute leukemia
Busulfan resistance
Hematological malignancies
Hematopoietic stem cell transplantation
Null genotypes of glutathione S-transferases
Post-transplant relapse

Affiliation entities

Research groups

Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)

Funding

FNS [ME9870/320030-153389]

Citation (ISO format)

MLAKAR, Simona et al. GSTM1 and GSTT1 double null genotypes determining cell fate and proliferation as potential risk factors of relapse in children with hematological malignancies after hematopoietic stem cell transplantation. In: Journal of cancer research and clinical oncology, 2022, vol. 148, n° 1, p. 71–86. doi: 10.1007/s00432-021-03769-2