To degrade a microRNA, destroy its argonaute protein

Wu, Pei-Hsuan; Zamore, Phillip D

doi:10.1016/j.molcel.2020.12.043

Scientific article

Comment

English

To degrade a microRNA, destroy its argonaute protein

ContributorsWu, Pei-Hsuan; Zamore, Phillip D

Published inMolecular cell, vol. 81, no. 2, p. 223-225

Publication date2021-01-21

Abstract

Han et al. (2020) and Shi et al. (2020) report that the E3 ubiquitin ligase ZSWIM8 senses when an RNA and an Argonaute protein-bound microRNA are extensively base paired and directs Argonaute destruction by the proteasome. The result is degradation of the microRNA.

Keywords

Argonaute Proteins / genetics
Argonaute Proteins / metabolism
MicroRNAs / genetics
Proteasome Endopeptidase Complex / metabolism
Ubiquitin / metabolism
Ubiquitin-Protein Ligases / metabolism

Affiliation entities

Not a UNIGE publication

Research groups

Fonction et mécanisme des petits ARN non codants germinaux dans le sperme et les embryons (1037)

Citation (ISO format)

WU, Pei-Hsuan, ZAMORE, Phillip D. To degrade a microRNA, destroy its argonaute protein. In: Molecular cell, 2021, vol. 81, n° 2, p. 223–225. doi: 10.1016/j.molcel.2020.12.043

Article (Published version)

Identifiers

PID : unige:160024
DOI : 10.1016/j.molcel.2020.12.043
PMID : 33482091

Additional URL for this publicationhttps://www.sciencedirect.com/science/article/pii/S1097276520309643

Journal ISSN1097-2765

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Creation30/03/2022 09:15:00

First validation30/03/2022 09:15:00

Update16/03/2023 06:20:05

Status update16/03/2023 06:20:04

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To degrade a microRNA, destroy its argonaute protein

Han et al. (2020) and Shi et al. (2020) report that the E3 ubiquitin ligase ZSWIM8 senses when an RNA and an Argonaute protein-bound microRNA are extensively base paired and directs Argonaute destruction by the proteasome. The result is degradation of the microRNA.

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