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Scientific article
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English

To degrade a microRNA, destroy its argonaute protein

Published inMolecular cell, vol. 81, no. 2, p. 223-225
Publication date2021-01-21
Abstract

Han et al. (2020) and Shi et al. (2020) report that the E3 ubiquitin ligase ZSWIM8 senses when an RNA and an Argonaute protein-bound microRNA are extensively base paired and directs Argonaute destruction by the proteasome. The result is degradation of the microRNA.

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Keywords
  • Argonaute Proteins / genetics
  • Argonaute Proteins / metabolism
  • MicroRNAs / genetics
  • Proteasome Endopeptidase Complex / metabolism
  • Ubiquitin / metabolism
  • Ubiquitin-Protein Ligases / metabolism
Affiliation Not a UNIGE publication
Citation (ISO format)
WU, Pei-Hsuan, ZAMORE, Phillip D. To degrade a microRNA, destroy its argonaute protein. In: Molecular cell, 2021, vol. 81, n° 2, p. 223–225. doi: 10.1016/j.molcel.2020.12.043
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ISSN of the journal1097-2765
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Creation03/30/2022 9:15:00 AM
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