en
Scientific article
Open access
English

Low vitamin D levels and increased neutrophil in patients admitted at ICU with COVID-19

Published inClinical nutrition ESPEN, vol. 44, p. 466-468
Publication date2021-08
First online date2021-05-31
Abstract

Background & aims: Systemic inflammation has been reported as a new predictor for COVID-19 outcomes. Thus, we hypothesized that ICU patients infected by COVID-19 had lower blood vitamin D levels and increased systemic inflammation. Therefore, this is the first Brazilian study to evaluate the vitamin D concentrations and NLR as a systemic inflammation in patients infected by COVID-19 admitted in ICU.

Methods: This cross-sectional study selected twenty-six patients from COVID-19 Data Sharing/FAPESP, Brazil. Twenty-five patients were enrolled from a single hospital and those with blood vitamin D and neutrophil and lymphocyte data were included and had all available data analyzed. Patients were divided in two groups: low vitamin D concentration when ≤20 ng/mL (low Vit D group, n = 8, 5M/3F, 62.7 ± 8.4 years old), and normal vitamin D when > 20 ng/mL (normal Vit D group, n = 17, 9M/8F, 74 ± 8.2 years old). Serum 25-hydroxy-vitamin D, C reactive protein (CRP), and count of neutrophils and lymphocytes concentrations were collected from COVID-19 Data Sharing/FAPESP. Statistical analyses were performed using the Prism version 5.0 and Student T test was applied to verify any difference between the groups.

Results: Low vitamin D group had 15.5 ± 3.3 ng/mL of 25OH Vit D concentrations and normal vitamin D group had 35.9 ± 8.8 ng/mL. Although no difference between groups for CRP concentrations (low Vit D: 4.5 ± 3.3 vs. normal Vit D: 4.2 ± 4.0 mg/dL, p = 0.45), we found higher neutrophil count and NLR values in the low Vit D group when compared to normal Vit D group (low Vit D: 6049.8 ± 3719.7 vs. normal Vit D: 3741.8 ± 1704.1 ng/mL, p = 0.02) and (low Vit D: 9.0 ± 8.6 vs. normal Vit D: 4.2 ± 4.0 ng/mL, p = 0.03), respectively.

Conclusion: This data sharing-derived cases of COVID-19 in patients admitted at ICU showed that patients infected by COVID-19 had lower serum 25-hydroxy vitamin D and enhanced systemic inflammation when assessed by NLR values.

eng
Keywords
  • COVID-19
  • ICU
  • Inflammation
  • Lymphocytes
  • Neutrophil
  • Vitamin D
Funding
  • The Brazilian National Council for Scientific and Technological Development (CNPq, Brazil) - [312252/2019-6]
Citation (ISO format)
PIMENTEL, Gustavo D., DELA VEGA, Maria C.M., PICHARD, Claude. Low vitamin D levels and increased neutrophil in patients admitted at ICU with COVID-19. In: Clinical nutrition ESPEN, 2021, vol. 44, p. 466–468. doi: 10.1016/j.clnesp.2021.05.021
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal2405-4577
116views
86downloads

Technical informations

Creation12/14/2021 10:46:00 AM
First validation12/14/2021 10:46:00 AM
Update time03/16/2023 2:57:45 AM
Status update03/16/2023 2:57:44 AM
Last indexation05/06/2024 10:31:21 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack