Scientific article
Open access

Effect of Levothyroxine Therapy on the Development of Depressive Symptoms in Older Adults With Subclinical Hypothyroidism

Published inJAMA network open, vol. 4, no. 2, e2036645
Publication date2021-02-10
First online date2021-02-10

Importance: Previous trials on the effect of levothyroxine on depressive symptom scores in patients with subclinical hypothyroidism were limited by small sample sizes (N = 57 to 94) and potential biases.

Objective: To assess the effect of levothyroxine on the development of depressive symptoms in older adults with subclinical hypothyroidism in the largest trial on this subject and to update a previous meta-analysis including the results from this study.

Design, setting, and participants: This predefined ancillary study analyzed data from participants in the Thyroid Hormone Replacement for Untreated Older Adults with Subclinical Hypothyroidism (TRUST) trial, a double-blind, randomized, placebo-controlled, parallel-group clinical trial conducted from April 2013 to October 31, 2016. The TRUST trial included adults aged 65 years or older diagnosed with subclinical hypothyroidism, defined as the presence of persistently elevated thyroid-stimulating hormone (TSH) levels (4.6-19.9 mIU/L) with free thyroxine (T4) within the reference range. Participants were identified from clinical and general practitioner laboratory databases and recruited from the community in Switzerland, the Netherlands, Ireland, and the UK. This ancillary study included a subgroup of 472 participants from the Netherlands and Switzerland; after exclusions, a total of 427 participants (211 randomized to levothyroxine and 216 to placebo) were analyzed. This analysis was conducted from December 1, 2019, to September 1, 2020.

Research group
Citation (ISO format)
WILDISEN, Lea et al. Effect of Levothyroxine Therapy on the Development of Depressive Symptoms in Older Adults With Subclinical Hypothyroidism. In: JAMA network open, 2021, vol. 4, n° 2, p. e2036645. doi: 10.1001/jamanetworkopen.2020.36645
Main files (1)
Article (Published version)
Secondary files (2)
ISSN of the journal2574-3805

Technical informations

Creation12/07/2021 4:46:00 PM
First validation12/07/2021 4:46:00 PM
Update time03/16/2023 2:57:34 AM
Status update03/16/2023 2:57:32 AM
Last indexation05/06/2024 10:31:03 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack