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Scientific article
Review
Open access
English

Combination of mesenchymal stem cells and bioactive molecules in hydrogels for osteoarthritis treatment

Publication date2022-01-31
First online date2022-01-31
Abstract

Osteoarthritis (OA) is a chronic and inflammatory disease with no effective regenerative treatments to date. The therapeutic potential of mesenchymal stem cells (MSCs) remains to be fully explored. Intra-articular injection of these cells promotes cartilage protection and regeneration by paracrine signaling and differentiation into chondrocytes. However, joints display a harsh avascular environment for these cells upon injection. This phenomenon prompted researchers to develop suitable injectable materials or systems for MSCs to enhance their function and survival. Among them, hydrogels can absorb a large amount of water and maintain their 3D structure but also allow incorporation of bioactive agents or small molecules in their matrix that maximize the action of MSCs. These materials possess advantageous cartilage-like features such as collagen or hyaluronic acid moieties that interact with MSC receptors, thereby promoting cell adhesion. This review provides an up-to-date overview of the progress and opportunities of MSCs entrapped into hydrogels, combined with bioactive/small molecules to improve the therapeutic effects in OA treatment.

eng
Keywords
  • Cartilage regeneration
  • Growth factors
  • Hydrogel
  • Mesenchymal stem cells
  • Osteoarthritis
  • Small molecule.
Citation (ISO format)
GONZALEZ FERNANDEZ, Paula et al. Combination of mesenchymal stem cells and bioactive molecules in hydrogels for osteoarthritis treatment. In: European journal of pharmaceutics and biopharmaceutics, 2022, vol. 172, p. 41–52. doi: 10.1016/j.ejpb.2022.01.003
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Article (Published version)
Identifiers
ISSN of the journal0939-6411
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Technical informations

Creation03/15/2022 9:09:00 AM
First validation03/15/2022 9:09:00 AM
Update time03/16/2023 2:54:11 AM
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