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Scientific article
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A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review

Published inBrachytherapy, vol. 20, no. 2, p. 478-484
Publication date2021
First online date2020-12-09
Abstract

Purpose: To describe experience with partial nephrectomy combined with brachytherapy as part of the local management of bilateral Wilms tumor (WT) including a review of the available literature.

Results (methods and case description): Between 2011 and 2014, three highly selected patients (age nine months, 16 months, and 4 years) with bilateral WT (two synchronous and one metachronous) underwent enucleation and perioperative brachytherapy to the tumor bed. With a minimum follow-up of 5 years, all three patients are in continuous complete remission with preserved kidney function.

Conclusions: Although nephron sparing surgery aiming at tumor free-margins remains the gold standard for bilateral WT, tumor enucleation followed by brachytherapy may be considered in carefully selected patients at high risk for end-stage kidney failure. Given the rarity and complexity of the procedure, concentration of care of such patients is mandatory.

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Keywords
  • Brachytherapy
  • Enucleation
  • Wilms tumor
  • Brachytherapy / methods
  • Follow-Up Studies
  • Humans
  • Infant, Newborn
  • Kidney Neoplasms / radiotherapy
  • Kidney Neoplasms / surgery
  • Nephrectomy
  • Retrospective Studies
  • Wilms Tumor / radiotherapy
  • Wilms Tumor / surgery
Citation (ISO format)
DÁVILA FAJARDO, Raquel et al. A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review. In: Brachytherapy, 2021, vol. 20, n° 2, p. 478–484. doi: 10.1016/j.brachy.2020.09.001
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ISSN of the journal1538-4721
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Creation10/08/2021 10:52:00 AM
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