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Function of the Interleukin (IL)-1 family member IL-38 in human keratinocytes

Defense Thèse de doctorat : Univ. Genève, 2021 - Sc. Vie - Bioméd. 129 - 2021/11/03
Abstract Interleukin (IL)-38 is a member of the IL-1 cytokine family, with the highest expression in differentiating keratinocytes and reported anti-inflammatory activity. However, little data are available regarding its biological functions such as inflammation, proliferation and differentiation in human keratinocytes. We demonstrate by immuno-staining that IL-38 is produced in multiple cell types of the skin and that IL-38 protein levels are downregulated in skin pathologies such as psoriasis and atopic dermatitis. Protein and mRNA quantification showed that IL-38 endogenous expression correlates with the state of keratinocyte differentiation. IL-38 ectopic overexpression in keratinocyte inhibits their proliferation and promotes their differentiation. Surprisingly, while our results did not demonstrate a significant anti-inflammatory activity of IL-38 in keratinocytes, IL-38 partially inhibited the inflammatory response in fibroblasts. Overall, our results indicate that IL-38 can act independently of the activation of the immune system and directly affect the epidermis. Our data point to an importance of keratinocyte-derived IL-38 in skin homeostasis and pathologies characterized by epidermal alterations.
URN: urn:nbn:ch:unige-1594297
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Research group Biologie des cytokines de la famille de l'interleukine-1 (1022)
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MERMOUD, Loïc Xavier. Function of the Interleukin (IL)-1 family member IL-38 in human keratinocytes. Université de Genève. Thèse, 2021. doi: 10.13097/archive-ouverte/unige:159429 https://archive-ouverte.unige.ch/unige:159429

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Deposited on : 2022-03-09

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