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Doctoral thesis
English

Anti-proliferative Natural Compounds and their Derivatives in various in vitro Multiple Myeloma Models

Number of pages248
Imprimatur date2022-02-03
Defense date2022-01-25
Abstract

MM is one of the most frequent hematological cancers, which until this day is considered an incurable disease. In the past years, several new drugs were introduced for the management of MM, which led to an improvement in overall survival. However, most patients relapse and their refractory disease is frequently resistant to conventional treatments. Thus, it is necessary to find new therapeutic strategies to overcome this resistance. The various chapters of this work follow the first steps of the preclinical drug discovery process, starting with the screening of natural and semi-synthetic compounds for their anti-proliferative activity in MM and studying their structure-activity relationship. This was followed by functional and mechanistic studies of one of the most active compounds. In the process, different MM models were established, namely PI resistant cells and 3D co-culture models.

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Citation (ISO format)
FARIA FREITAS MISAKYAN, Micaela. Anti-proliferative Natural Compounds and their Derivatives in various in vitro Multiple Myeloma Models. 2022. doi: 10.13097/archive-ouverte/unige:159418
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Creation02/28/2022 3:18:00 PM
First validation02/28/2022 3:18:00 PM
Update time07/31/2023 11:29:01 AM
Status update07/31/2023 11:29:01 AM
Last indexation02/01/2024 7:53:45 AM
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