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Scientific article
Open access
English

Predictors of breakthrough clinically significant cytomegalovirus infection during letermovir prophylaxis in high-risk hematopoietic cell transplant recipients

Published inImmunity, inflammation and disease, vol. 9, no. 3, p. 771-776
Publication date2021-09
First online date2021-05-05
Abstract

Letermovir prophylaxis in allogeneic hematopoietic cell transplant recipients significantly reduces the incidence of clinically significant cytomegalovirus infection. However, breakthrough infections still occur despite adequate prophylaxis. In the present retrospective cohort study, we identified clinically relevant predictive factors for clinically significant CMV breakthrough infection during letermovir prophylaxis. Low-grade CMV replication (21-149 IU/ml), both at the time of letermovir initiation or during prophylaxis, was a significant risk factor for breakthrough clinically significant CMV infection. In addition, development of acute gastrointestinal graft-versus-host disease was significantly associated with breakthrough infection. Altogether these findings could call clinicians' attention to closer CMV monitoring and allow for prompt preemptive treatment initiation.

eng
Keywords
  • Allogeneic hematopoietic cell transplant recipients
  • Breakthrough infection
  • Cytomegalovirus (CMV)
  • Letermovir
  • Prophylaxis
  • Risk factors
  • Acetates
  • Antiviral Agents / therapeutic use
  • Cytomegalovirus
  • Cytomegalovirus Infections / drug therapy
  • Cytomegalovirus Infections / epidemiology
  • Cytomegalovirus Infections / prevention & control
  • Hematopoietic Stem Cell Transplantation / adverse effects
  • Humans
  • Quinazolines
  • Retrospective Studies
  • Transplant Recipients
Citation (ISO format)
ROYSTON, Lena et al. Predictors of breakthrough clinically significant cytomegalovirus infection during letermovir prophylaxis in high-risk hematopoietic cell transplant recipients. In: Immunity, inflammation and disease, 2021, vol. 9, n° 3, p. 771–776. doi: 10.1002/iid3.431
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Article (Published version)
Identifiers
ISSN of the journal2050-4527
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Technical informations

Creation10/21/2021 8:14:00 AM
First validation10/21/2021 8:14:00 AM
Update time03/16/2023 2:48:51 AM
Status update03/16/2023 2:48:50 AM
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