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Distribution of Aspergillus Species and Prevalence of Azole Resistance in Respiratory Samples From Swiss Tertiary Care Hospitals

ContributorsRagozzino, Silvioorcid; Goldenberger, Daniel; Wright, Patrick Rorcid; Zimmerli, Stefan; Mühlethaler, Konrad; Neofytos, Dionysiosorcid; Riat, Arnaud; Boggian, Katia; Nolte, Oliver; Conen, Anna; Fankhauser, Hans; Schreiber, Peter W; Zbinden, Reinhard; Lamoth, Frederic; Khanna, Ninaorcid
Published inOpen forum infectious diseases, vol. 9, no. 2, ofab638
Publication date2022-02
First online date2021-12-18
Abstract

Among 400 Aspergillus species from respiratory samples in Switzerland, Aspergillus fumigatus was the most frequent species. Non-fumigatus Aspergillus spp were more prevalent among solid organ transplant recipients and after azole exposure. Azole resistance was detected in 4 A fumigatus isolates, 3 of them with the "environmental" mutation TR34/L98H in the cyp51A gene.

Keywords
  • Aspergillus fumigatus
  • TR34/L98H mutation
  • Azole resistance
  • Cyp51A gene
  • Non-fumigatus Aspergillus spp
UNIGE affiliation entities
Citation (ISO format)
RAGOZZINO, Silvio et al. Distribution of Aspergillus Species and Prevalence of Azole Resistance in Respiratory Samples From Swiss Tertiary Care Hospitals. In: Open forum infectious diseases, 2022, vol. 9, n° 2, p. ofab638. doi: 10.1093/ofid/ofab638
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Additional URL for this publicationhttps://academic.oup.com/ofid/article/9/2/ofab638/6469897
Journal ISSN2328-8957
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215downloads

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