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Distribution of Aspergillus Species and Prevalence of Azole Resistance in Respiratory Samples From Swiss Tertiary Care Hospitals

ContributorsRagozzino, Silvioorcid; Goldenberger, Daniel; Wright, Patrick Rorcid; Zimmerli, Stefan; Mühlethaler, Konrad; Neofytos, Dionysiosorcid; Riat, Arnaud; Boggian, Katia; Nolte, Oliver; Conen, Anna; Fankhauser, Hans; Schreiber, Peter W; Zbinden, Reinhard; Lamoth, Frederic; Khanna, Ninaorcid
Published inOpen forum infectious diseases, vol. 9, no. 2, ofab638
Publication date2022-02
First online date2021-12-18
Abstract

Among 400 Aspergillus species from respiratory samples in Switzerland, Aspergillus fumigatus was the most frequent species. Non-fumigatus Aspergillus spp were more prevalent among solid organ transplant recipients and after azole exposure. Azole resistance was detected in 4 A fumigatus isolates, 3 of them with the "environmental" mutation TR34/L98H in the cyp51A gene.

Keywords
  • Aspergillus fumigatus
  • TR34/L98H mutation
  • Azole resistance
  • Cyp51A gene
  • Non-fumigatus Aspergillus spp
Affiliation entities
Citation (ISO format)
RAGOZZINO, Silvio et al. Distribution of Aspergillus Species and Prevalence of Azole Resistance in Respiratory Samples From Swiss Tertiary Care Hospitals. In: Open forum infectious diseases, 2022, vol. 9, n° 2, p. ofab638. doi: 10.1093/ofid/ofab638
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accessLevelPublic CC BY-NC-ND-4.0
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Identifiers
Additional URL for this publicationhttps://academic.oup.com/ofid/article/9/2/ofab638/6469897
Journal ISSN2328-8957
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