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Doctoral thesis
Open access
English

Efficient Strategies for Metabolite Profiling and Isolation of Antimicrobial Natural Products from the Fungal Endophyte Community of the Seagrass Posidonia oceanica

Number of pages409
Imprimatur date2022-01-18
Defense date2021-12-07
Abstract

Antimicrobial resistance is a major global concern affecting public health. In this context, natural products (NPs) represent a reservoir of unique chemical scaffolds with potential antimicrobial properties. At present, the majority of naturally originated antibiotics have been isolated from soil microorganisms. Thus, investigation of NPs from marine endophytic strains in this regard is an expanding field. This thesis is within the frame of SECIL, a collaborative project between different research units in Switzerland and France which aims to perform a comprehensive study of the endophytic communities within model plants. In the present work, we investigated in particular the fungal endophytes within the tissues of the seagrass Posidonia oceanica. The main goal was to search for bioactive agents and to report new chemical entities biosynthesized by those endophytes. In total, 53 fungal metabolites from 6 selected strains were fully identified and their bioactive potential was evaluated.

eng
Keywords
  • Posidonia oceanica
  • Fungal endophytes
  • UHPLC-HRMS/MS molecular networking
  • High resolution semi-preparative HPLC
  • Antimicrobial natural products
  • Anti-quorum sensing assays
Citation (ISO format)
ALFATTANI, Abdulelah. Efficient Strategies for Metabolite Profiling and Isolation of Antimicrobial Natural Products from the Fungal Endophyte Community of the Seagrass Posidonia oceanica. 2022. doi: 10.13097/archive-ouverte/unige:159354
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Creation02/16/2022 10:30:00 AM
First validation02/16/2022 10:30:00 AM
Update time04/24/2023 9:29:29 AM
Status update04/24/2023 9:29:29 AM
Last indexation05/06/2024 10:13:39 AM
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