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Scientific article
English

Mycobacterium ulcerans-specific immune response after immunisation with bacillus Calmette-Guérin (BCG) vaccine

Published inVaccine, vol. 39, no. 4, p. 652-657
Publication date2021-01-22
First online date2020-12-25
Abstract

Background: Bacillus Calmette-Guérin (BCG) vaccine provides partial protection against Buruli ulcer caused by Mycobacterium ulcerans in epidemiological studies. This study aimed to quantify M. ulcerans-specific immune responses induced by BCG immunisation. Methods: Intracellular cytokine analysis of in-vitro experiments done 10 weeks after BCG immunisation in 130 Australian infants randomised to one of three BCG vaccine strains given either at birth (BCG-Denmark, BCG-Japan, or BCG-Russia) or at two months of age (BCG-Denmark). Results: Proportions of polyfunctional CD4+ T-cells were higher in M. ulcerans-stimulated compared to unstimulated control samples. These proportions were not influenced by the vaccine strain or timing of the immunisation. The M. ulcerans-specific immune responses showed similar patterns to those observed in M. tuberculosis-stimulated samples, although they were of lower magnitude. Conclusions: Our data show that BCG immunisation induces M. ulcerans-specific immune responses in infants, likely explaining the cross-protective effect observed in epidemiological studies. (ACTRN12608000227392).

eng
Keywords
  • Buruli ulcer
  • Cross-protection
  • Mycobacterium bovis
  • Mycolactone
  • Prevention
  • Randomised controlled trial
  • Australia
  • BCG Vaccine
  • Humans
  • Immunity
  • Immunization
  • Infant
  • Japan
  • Mycobacterium ulcerans
  • Russia
Affiliation Not a UNIGE publication
Citation (ISO format)
PITTET, Laure et al. Mycobacterium ulcerans-specific immune response after immunisation with bacillus Calmette-Guérin (BCG) vaccine. In: Vaccine, 2021, vol. 39, n° 4, p. 652–657. doi: 10.1016/j.vaccine.2020.11.045
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Identifiers
ISSN of the journal0264-410X
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Creation10/08/2021 9:33:00 AM
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