en
Scientific article
Case report
English

Successful treatment of central nervous system lymphoproliferative disorder in a kidney-pancreas and stem cell transplanted patient using intrathecal rituximab

Published inBMJ case reports, vol. 14, no. 8, e238236
Publication date2021-08-05
First online date2021-08-05
Abstract

Central nervous system lymphoproliferative disorder (CNS-PTLD) after organ transplant is a unique clinicopathological entity and is associated with poor survival rates. When the CNS is involved, intravenous rituximab might not be the treatment of choice, due to its poor CNS penetration. However, intrathecal (IT) administration of rituximab has shown to be safe and efficient in small studies and in case series. We report here the case of a patient with late development of CNS-PTLD after kidney-pancreas transplantation who achieved complete remission after surgical resection and four cycles of IT rituximab and we provide a review of the literature for this treatment option.

eng
Keywords
  • CNS cancer
  • Haematology (drugs and medicines)
  • Haematology (incl blood transfusion)
  • Malignant disease and immunosuppression
  • Neuroimaging
  • Antibodies, Monoclonal, Murine-Derived
  • Central Nervous System
  • Humans
  • Kidney
  • Lymphoproliferative Disorders / drug therapy
  • Pancreas
  • Rituximab
  • Stem Cells
Citation (ISO format)
ANASTASIOU, Maria et al. Successful treatment of central nervous system lymphoproliferative disorder in a kidney-pancreas and stem cell transplanted patient using intrathecal rituximab. In: BMJ case reports, 2021, vol. 14, n° 8, p. e238236. doi: 10.1136/bcr-2020-238236
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Article (Published version)
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ISSN of the journal1757-790X
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Creation10/21/2021 8:14:00 AM
First validation10/21/2021 8:14:00 AM
Update time03/16/2023 2:41:36 AM
Status update03/16/2023 2:41:35 AM
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