Scientific article

Genes of Type 2 Diabetes in β Cells

Published inEndocrinology and metabolism clinics of North America, vol. 35, no. 2, p. 357-369
Publication date2006-06

Type 2 diabetes is a complex polygenic metabolic disorder of epidemic proportions. This review provides a brief overview of the susceptibility genes in type 2 diabetes that primarily affect pancreatic 3 cells, with emphasis on their function and most relevant polymorphisms. We focus on calpain 10, the only susceptibility gene identified thus far through a positional cloning approach in subjects with diabetes.

  • Autoantigens / genetics
  • Autoantigens / physiology
  • Calpain / genetics
  • Calpain / physiology
  • Diabetes Mellitus, Type 2 / genetics
  • Diabetes Mellitus, Type 2 / physiopathology
  • Genetic Predisposition to Disease
  • Humans
  • Insulin-Secreting Cells / physiology
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology
  • Polymorphism, Genetic
  • Protein Tyrosine Phosphatases / genetics
  • Protein Tyrosine Phosphatases / physiology
  • Receptor-Like Protein Tyrosine Phosphatases, Class 8
Affiliation Not a UNIGE publication
Citation (ISO format)
TRAJKOVSKI, Mirko et al. Genes of Type 2 Diabetes in β Cells. In: Endocrinology and metabolism clinics of North America, 2006, vol. 35, n° 2, p. 357–369. doi: 10.1016/j.ecl.2006.02.008
Main files (1)
Article (Published version)
ISSN of the journal0889-8529

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