UNIGE document Scientific Article - Review
previous document  unige:158886  next document
add to browser collection

Neuroimaging in Functional Neurological Disorder: State of the Field and Research Agenda

Perez, David L.
Nicholson, Timothy R.
Asadi-Pooya, Ali A.
Butler, Matthew
Carson, Alan J.
David, Anthony S.
Deeley, Quinton
show hidden authors show all authors [1 - 30]
Published in NeuroImage. Clinical. 2021, vol. 30, 102623
Abstract Functional neurological disorder (FND) was of great interest to early clinical neuroscience leaders. During the 20th century, neurology and psychiatry grew apart – leaving FND a borderland condition. Fortunately, a renaissance has occurred in the last two decades, fostered by increased recognition that FND is prevalent and diagnosed using “rule-in” examination signs. The parallel use of scientific tools to bridge brain structure - function relationships has helped refine an integrated biopsychosocial framework through which to conceptualize FND. In particular, a growing number of quality neuroimaging studies using a variety of methodologies have shed light on the emerging pathophysiology of FND. This renewed scientific interest has occurred in parallel with enhanced interdisciplinary collaborations, as illustrated by new care models combining psychological and physical therapies and the creation of a new multidisciplinary FND society supporting knowledge dissemination in the field. Within this context, this article summarizes the output of the first International FND Neuroimaging Workgroup meeting, held virtually, on June 17th, 2020 to appraise the state of neuroimaging research in the field and to catalyze large-scale collaborations. We first briefly summarize neural circuit models of FND, and then detail the research approaches used to date in FND within core content areas: cohort characterization; control group considerations; task-based functional neuroimaging; resting-state networks; structural neuroimaging; biomarkers of symptom severity and risk of illness; and predictors of treatment response and prognosis. Lastly, we outline a neuroimaging-focused research agenda to elucidate the pathophysiology of FND and aid the development of novel biologically and psychologically-informed treatments.
Keywords Conversion disorderDTIFunctional neurological disorderMRINeuroimagingfMRI
PMID: 34215138
PMCID: PMC8111317
Full text
Research group Psychopathologie clinique et expérimentale (987)
Swiss National Science Foundation: PP00P3_176985
(ISO format)
PEREZ, David L. et al. Neuroimaging in Functional Neurological Disorder: State of the Field and Research Agenda. In: NeuroImage. Clinical, 2021, vol. 30, p. 102623. doi: 10.1016/j.nicl.2021.102623 https://archive-ouverte.unige.ch/unige:158886

43 hits



Deposited on : 2022-02-11

Export document
Format :
Citation style :