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Scientific article
English

Gd3+ -Functionalized Lithium Niobate Nanoparticles for Dual Multiphoton and Magnetic Resonance Bioimaging

Publication date2022-02-03
First online date2022-02-03
Abstract

Harmonic nanoparticles (HNPs) have emerged as appealing exogenous probes for optical bioimaging due to their distinctive features such as long-term photostability and spectral flexibility, allowing multiphoton excitation in the classical (NIR-I) and extended near-infrared spectral windows (NIR-II and -III). However, like all other optical labels, HNPs are not suitable for whole-body imaging applications. In this work, we developed a bimodal nonlinear optical/magnetic resonance imaging (MRI) contrast agent through the covalent conjugation of Gd(III) chelates to coated lithium niobate HNPs. We show that the resulting nanoconjugates exert strong contrast both in T1-weighted MRI of agarose gel-based phantoms and in cancer cells by harmonic generation upon excitation in the NIR region. Their capabilities for dual T1/T2 MRI were also emphasized by the quantitative mapping of the phantom in both modes. The functionalization protocol ensured high stability of the Gd-functionalized HNPs in a physiological environment and provided a high r1 relaxivity value per NP (5.20 × 105 mM–1 s–1) while preserving their efficient nonlinear optical response.

eng
Keywords
  • Biological imaging
  • Imaging agents
  • Magnetic resonance imaging
  • Nonlinear optics
Research group
Citation (ISO format)
DE MATOS, Raphaël et al. Gd<sup>3+</sup> -Functionalized Lithium Niobate Nanoparticles for Dual Multiphoton and Magnetic Resonance Bioimaging. In: ACS applied nano materials, 2022. doi: 10.1021/acsanm.2c00127
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ISSN of the journal2574-0970
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Creation02/04/2022 10:40:00 AM
First validation02/04/2022 10:40:00 AM
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