en
Scientific article
English

Effect of Neoadjuvant Chemotherapy Followed by Surgical Resection on Survival in Patients With Limited Metastatic Gastric or Gastroesophageal Junction Cancer: The AIO-FLOT3 Trial

Published inJAMA oncology, vol. 3, no. 9, p. 1237-1244
Publication date2017-09-01
First online date2017-04-27
Abstract

KEY POINTS

Question: Is there a survival benefit for patients with limited metastatic gastric or gastroesophageal junction cancer who receive neoadjuvant chemotherapy followed by surgical resection?

Findings: In this phase 2 trial that enrolled 252 patients with resectable or metastatic gastric or gastroesophageal junction adenocarcinoma, 60 of the 238 eligible patients were classified as having limited metastatic stage and 36 of these 60 patients had surgery, including resection of the primary tumor and metastases. The median overall survival was 31.3 months for patients who underwent surgery and 15.9 months for the other patients.

Meaning: Patients with limited metastatic gastric or gastroesophageal junction cancer may benefit from neoadjuvant chemotherapy followed by surgical resection.

eng
Keywords
  • Adenocarcinoma / drug therapy
  • Adenocarcinoma / secondary
  • Adenocarcinoma / surgery
  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Chemotherapy, Adjuvant
  • Docetaxel
  • Esophagogastric Junction
  • Fluorouracil / administration & dosage
  • Gastrectomy
  • Humans
  • Leucovorin / administration & dosage
  • Liver Neoplasms / drug therapy
  • Liver Neoplasms / secondary
  • Liver Neoplasms / surgery
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / secondary
  • Lung Neoplasms / surgery
  • Lymphatic Metastasis
  • Metastasectomy
  • Middle Aged
  • Neoadjuvant Therapy
  • Neoplasm Staging
  • Organoplatinum Compounds / administration & dosage
  • Oxaliplatin
  • Peritoneal Neoplasms / drug therapy
  • Peritoneal Neoplasms / secondary
  • Peritoneal Neoplasms / surgery
  • Prospective Studies
  • Stomach Neoplasms / drug therapy
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / surgery
  • Survival Rate
  • Taxoids / administration & dosage
  • Young Adult
Affiliation Not a UNIGE publication
Citation (ISO format)
AL-BATRAN, Salah-Eddin et al. Effect of Neoadjuvant Chemotherapy Followed by Surgical Resection on Survival in Patients With Limited Metastatic Gastric or Gastroesophageal Junction Cancer: The AIO-FLOT3 Trial. In: JAMA oncology, 2017, vol. 3, n° 9, p. 1237–1244. doi: 10.1001/jamaoncol.2017.0515
Main files (1)
Article (Published version)
accessLevelRestricted
Secondary files (2)
Identifiers
ISSN of the journal2374-2437
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Technical informations

Creation01/31/2022 4:44:00 PM
First validation01/31/2022 4:44:00 PM
Update time03/16/2023 2:35:38 AM
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