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Scientific article
Case report
Open access
English

Unexpected acceleration in treprostinil delivery administered by a Lenus Pro® implantable pump in two patients treated for pulmonary arterial hypertension

Published inFrontiers in medicine, 539707
Publication date2020-10-30
First online date2020-10-30
Abstract

Intravenous treprostinil administration by an implantable pump is an attractive option for pulmonary arterial hypertension (PAH) treatment and is the subject of recent publications. Short-term studies are promising, but there is still a lack of long-term prospective data. We analyzed the treprostinil flow rate administered by the Lenus Pro® implantable pump in 2 patients suffering from PAH during follow-up times of respectively 4.2 and 3 years. The flow rate delivered by the pumps in these 2 patients exceeded the manufacturer admitted margin of error within 2 years and continued to increase to reach, respectively, 158 and 120% of the expected flow rate at the end of the follow up. In one case, the implantable pump had to be removed for this reason. The ex-vivo flow rate of the withdrawn pump determined in the laboratory reached 173% of the predicted value. This correlated with the in-vivo measurement, which suggests a continuous flow increase even after pump removal and without treprostinil use. Spontaneous flow increase from such an implantable pump is a potentially major pitfall, which needs to be identified and actively managed by the responsible clinicians.

eng
Keywords
  • Implantable pump
  • Internal device
  • Prostacyclin analogs
  • Pulmonary arterial hypertension
  • Treprostinil delivery
Citation (ISO format)
KOPP, Garance et al. Unexpected acceleration in treprostinil delivery administered by a Lenus Pro® implantable pump in two patients treated for pulmonary arterial hypertension. In: Frontiers in medicine, 2020, p. 539707. doi: 10.3389/fmed.2020.539707
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Article (Published version)
Identifiers
ISSN of the journal2296-858X
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