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Title

Unexpected acceleration in treprostinil delivery administered by a Lenus Pro® implantable pump in two patients treated for pulmonary arterial hypertension

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Published in Frontiers in medicine. 2020, 539707
Abstract Intravenous treprostinil administration by an implantable pump is an attractive option for pulmonary arterial hypertension (PAH) treatment and is the subject of recent publications. Short-term studies are promising, but there is still a lack of long-term prospective data. We analyzed the treprostinil flow rate administered by the Lenus Pro® implantable pump in 2 patients suffering from PAH during follow-up times of respectively 4.2 and 3 years. The flow rate delivered by the pumps in these 2 patients exceeded the manufacturer admitted margin of error within 2 years and continued to increase to reach, respectively, 158 and 120% of the expected flow rate at the end of the follow up. In one case, the implantable pump had to be removed for this reason. The ex-vivo flow rate of the withdrawn pump determined in the laboratory reached 173% of the predicted value. This correlated with the in-vivo measurement, which suggests a continuous flow increase even after pump removal and without treprostinil use. Spontaneous flow increase from such an implantable pump is a potentially major pitfall, which needs to be identified and actively managed by the responsible clinicians.
Keywords Implantable pumpInternal deviceProstacyclin analogsPulmonary arterial hypertensionTreprostinil delivery
Identifiers
PMID: 33195292
PMCID: PMC7662390
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Article (Published version) (572 Kb) - public document Free access
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Research groups Groupe Gasche-Soccal Paola (958)
L'hypertension pulmonaire (pédiatrie) (228)
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KOPP, Garance et al. Unexpected acceleration in treprostinil delivery administered by a Lenus Pro® implantable pump in two patients treated for pulmonary arterial hypertension. In: Frontiers in medicine, 2020, p. 539707. doi: 10.3389/fmed.2020.539707 https://archive-ouverte.unige.ch/unige:158686

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Deposited on : 2022-02-07

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