Scientific article
English

39·0°C versus 38·5°C ear temperature as fever limit in children with neutropenia undergoing chemotherapy for cancer: a multicentre, cluster-randomised, multiple-crossover, non-inferiority trial

Published inThe Lancet. Child & adolescent health., vol. 4, no. 7, p. 495-502
Publication date2020-07
First online date2020-06-01
Abstract

Fever in neutropenia is the most frequent complication of chemotherapy for cancer. The temperature limit defining fever used clinically varies. A higher limit can avoid unnecessary diagnoses in patients spontaneously recovering from fever. This trial primarily aimed to determine if a limit of 39·0°C ear temperature is non-inferior to 38·5°C regarding safety.

Keywords
  • Adolescent
  • Antineoplastic Agents / therapeutic use
  • Bacteremia / epidemiology
  • Body Temperature
  • Child
  • Child, Preschool
  • Cross-Over Studies
  • Ear
  • Febrile Neutropenia / diagnosis
  • Female
  • Humans
  • Intensive Care Units, Pediatric
  • Male
  • Neoplasms / therapy
  • Patient Admission / statistics & numerical data
  • Prospective Studies
  • Sepsis / epidemiology
Funding
  • Swiss Cancer League [KLS-3645-02-2015]
Citation (ISO format)
KOENIG, Christa et al. 39·0°C versus 38·5°C ear temperature as fever limit in children with neutropenia undergoing chemotherapy for cancer: a multicentre, cluster-randomised, multiple-crossover, non-inferiority trial. In: The Lancet. Child & adolescent health., 2020, vol. 4, n° 7, p. 495–502. doi: 10.1016/S2352-4642(20)30092-4
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN2352-4642
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